Comparing Efficacy of Three Methods of Tranexamic Acid Administration in Reducing Hemoglobin Drop Following Total Knee Arthroplasty

• Published in: The Journal of arthroplasty Vol. 29; no. 8; pp. 1521 - 1524
• Main Authors: Sarzaeem, Mohammad Mahdi, MD, Razi, Mohammad, MD, Kazemian, Gholamhosein, MD, Moghaddam, Mohammad Emami, MD, Rasi, Alireza Manafi, MD, Karimi, Meysam, MBE
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2014
• Subjects: Aged; Antifibrinolytic Agents - administration & dosage; Arthroplasty, Replacement, Knee - adverse effects; Blood Loss, Surgical - prevention & control; Blood Transfusion; Drainage - methods; Female; hemoglobin drop; Hemoglobins - metabolism; Humans; Injections, Intra-Articular; Injections, Intravenous; intra-articular injection; intravenous injection; Male; Middle Aged; Orthopedics; Sodium Chloride - administration & dosage; total knee arthroplasty; tranexamic acid; Tranexamic Acid - administration & dosage; Treatment Outcome; total knee arthroplasty; hemoglobin drop; intra-articular injection; intravenous injection; tranexamic acid
• ISSN: 0883-5403; 1532-8406
• DOI: 10.1016/j.arth.2014.02.031

Abstract The ideal method of providing tranexamic acid (TXA) for decreasing hemoglobin drop after TKA is still controversial. In this clinical trial, 200 patients were randomly allocated to four groups. In group 1, 500 mg TXA was administered intravenously. In group 2, the joint irrigated with 3 g of TXA in 100 cc of saline. In group 3, 1.5 g of TXA was injected through the drain. Group 4 did not take TXA. Albeit all methods had a statistical effect on hemoglobin drop, drainage and number of transfused units when compared to controls, but intravenous injection of TXA seems to be much more effective in terms of reducing hemoglobin drop and transfused units; and what's more TXA injection by drain is more effective regarding to reducing postoperative drainage.