Progress in molecular typing of Mycobacterium avium subspecies paratuberculosis

• Published in: Research in veterinary science Vol. 92; no. 2; pp. 169 - 179
• Main Authors: Castellanos, Elena, Juan, Lucía de, Domínguez, Lucas, Aranaz, Alicia
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.04.2012; Elsevier Limited
• Subjects: Animals; DNA, Bacterial - genetics; Epidemiology; Genes, Bacterial - genetics; Genetics; Genomes; Humans; Johne’s disease; Methods; Microbiology; Milk; Molecular typing; Molecular Typing - methods; Mycobacterium avium; Mycobacterium avium subsp. paratuberculosis - genetics; Mycobacterium avium subspecies paratuberculosis; Oligonucleotide Array Sequence Analysis - methods; Paratuberculosis - diagnosis; Paratuberculosis - microbiology; Review; Studies; Types; Types; Molecular typing; Mycobacterium avium subspecies paratuberculosis; Review; Johne’s disease
• ISSN: 0034-5288; 1532-2661
• DOI: 10.1016/j.rvsc.2011.05.017

Mycobacterium avium subspecies paratuberculosis (M. a. paratuberculosis) is responsible for paratuberculosis or Johne’s disease, a chronic inflammation of the gastrointestinal tract in different animal species. Some studies have also established a link between this microorganism and Crohn’s disease in humans. Although, M. a. paratuberculosis is a difficult microorganism to cultivate in the laboratory (occasionally is non-cultivable), a proper molecular characterization of M. a. paratuberculosis is necessary to better understand the epidemiology of the disease, and design strategies to eradicate it. In the present review, we compile and discuss the recent progress attained in the diagnostic and characterization of this pathogen.