Immune mechanisms of Concanavalin A model of autoimmune hepatitis

As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis （AIH） have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is conside...

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Bibliographic Details
Published inWorld journal of gastroenterology : WJG Vol. 18; no. 2; pp. 119 - 125
Main Author Wang, Hai-Xia
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 14.01.2012
Subjects
Animals
Concanavalin A - pharmacology
Cytokines - immunology
Disease Models, Animal
Hepatitis, Autoimmune - drug therapy
Hepatitis, Autoimmune - etiology
Hepatitis, Autoimmune - immunology
Hepatitis, Autoimmune - pathology
Humans
Immunosuppressive Agents - therapeutic use
Liver - drug effects
Liver - immunology
Liver - pathology
Mitogens - pharmacology
Review
T-Lymphocytes - immunology
伴刀豆球蛋白A
免疫机制
刀豆素A
动物模型
发病机制
实验模型
肝炎
自身免疫性
Concanavalin A
Animal models
Autoimmune hepatitis
Online AccessGet full text
ISSN1007-9327
2219-2840
2219-2840
DOI10.3748/wjg.v18.i2.119

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Summary:As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis （AIH） have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A （Con A） model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development.
Bibliography:As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis （AIH） have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A （Con A） model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development.
14-1219/R
Autoimmune hepatitis; Animal models;Concanavalin A
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Author contributions: Wang HX and Liu M were the first authors; Wang HX and Liu M wrote the paper; Weng SY, Li JJ, Xie C, He HL, Guan W and Yuan YS contributed equally to this paper; Weng SY was in charge of revision; Li JJ and He HL contributed new drawing software and made the picture perfect; Xie C, Guan W and Yuan YS made a second revision; and Gao J brought up the idea and organized the manuscript.
Correspondence to: Jin Gao, PhD, Laboratory of Regeneration, School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Min Hang District, Shanghai 200240, China. g_jin@sjtu.edu.cn
Telephone: +86-21-34205769 Fax: +86-21-34204760
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v18.i2.119