Use of a low refractive index prism in surface plasmon resonance biosensing

A way to improve the angular sensitivity of surface plasmon resonance (SPR) biosensor by tuning the resonance position to a higher incident angle region using a lower refractive index glass prism is described in this paper. A novel effective 3-layer (E3L) model is described to transform a multiple l...

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Bibliographic Details
Published inSensors and actuators. B, Chemical Vol. 130; no. 2; pp. 689 - 695
Main Authors Gupta, Gaurav, Sugimoto, Mitsunori, Matsui, Yoshikazu, Kondoh, Jun
Format Journal Article
LanguageEnglish
Published Elsevier B.V 28.03.2008
Subjects
Biosensor
Effective 3-layer model
Glass prism
Refractive index
Surface plasmon resonance
Glass prism
Surface plasmon resonance
Effective 3-layer model
Biosensor
Refractive index
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Summary:A way to improve the angular sensitivity of surface plasmon resonance (SPR) biosensor by tuning the resonance position to a higher incident angle region using a lower refractive index glass prism is described in this paper. A novel effective 3-layer (E3L) model is described to transform a multiple layer biosensor configuration in context of SPR condition. The E3L model supports the use of a low refractive index prism for biosensing. The performance of the sensor in immunosensing is checked for two glass prisms of different refractive index materials. The experimental results showed an enhancement in the amount of resonance angle shift of the immunosensor for the lower refractive index glass prism.
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ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2007.10.029