Cytotoxic taraxerane triterpenoids from Saussurea graminea

• Published in: Fitoterapia Vol. 83; no. 1; pp. 55 - 59
• Main Authors: Hu, Jiang, Shi, Xiaodong, Chen, Jiangang, Huang, Huifu, Zhao, Congcong
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 2012; Elsevier
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Biological and medical sciences; Cell Line, Tumor; Compositae; Cytotoxicity; General pharmacology; Humans; Medical sciences; Molecular Structure; nuclear magnetic resonance spectroscopy; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Saussurea; Saussurea - chemistry; Saussurea graminea; Taraxerane triterpenoids; Triterpenes - chemistry; Triterpenes - pharmacology; triterpenoids; Taraxerane triterpenoids; Cytotoxicity; Compositae; Saussurea graminea; Terpenoid; Pharmacognosy; Dicotyledones; Angiospermae; Plant origin; Triterpene; Spermatophyta; Medicinal plant
• ISSN: 0367-326X; 1873-6971
• DOI: 10.1016/j.fitote.2011.09.009

Four new taraxerane triterpenoids, 1 β,3 β-dihydroxy-11 α,12 α-oxidotaraxerane (1), 28-hydroxy-11 α,12 α-oxidotaraxerane-3-one (2), 3 β-hydroxy-11 α,12 α-oxidotaraxerane-28-al (3), and 3- O-acetyl-11 α,12 α-oxidotaraxerane-28-al (4), together with three known compounds 3 β-hydroxy-11 α,12 α-oxidotaraxerane (5), 3 β,28-dihydroxy-11 α,12 α-oxidotaraxerane (6), and 11 α,12 α-oxidotaraxerane-3-one (7), were isolated from the 70% EtOH extract of Saussurea graminea. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties against eight tumor cell lines (A-549, BGC-823, HCT15, HeLa, HepG2, MCF-7, SGC-7901 and SK-MEL-2). [Display omitted]