Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review

• Published in: The American journal of tropical medicine and hygiene Vol. 102; no. 5; pp. 934 - 939
• Main Authors: Odedra, Anand, McCarthy, James S.
• Format: Journal Article
• Language: English
• Published: United States Institute of Tropical Medicine 01.05.2020; The American Society of Tropical Medicine and Hygiene
• Subjects: Animals; Anopheles - parasitology; Biomedical Research - methods; Biomedical Research - standards; Drug development; Human subjects; Humans; Infections; Malaria; Malaria - parasitology; Malaria - therapy; Medical research; Patient safety; Plasmodium; Research Subjects; Review; Risk Factors; Safety

Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of thes...