Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review

Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of thes...

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Published inThe American journal of tropical medicine and hygiene Vol. 102; no. 5; pp. 934 - 939
Main Authors Odedra, Anand, McCarthy, James S.
Format Journal Article
LanguageEnglish
Published United States Institute of Tropical Medicine 01.05.2020
The American Society of Tropical Medicine and Hygiene
Subjects
Animals
Anopheles - parasitology
Biomedical Research - methods
Biomedical Research - standards
Drug development
Human subjects
Humans
Infections
Malaria
Malaria - parasitology
Malaria - therapy
Medical research
Patient safety
Plasmodium
Research Subjects
Review
Risk Factors
Safety
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Summary:Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings.
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Authors’ addresses: Anand Odedra, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, E-mail: anand.odedra@lstmed.ac.uk. James S McCarthy, QIMR Berghofer Medical Research Institute, Brisbane, Australia, E-mail: james.mccarthy@qimrberghofer.edu.au.
ISSN:0002-9637
1476-1645
1476-1645
DOI:10.4269/ajtmh.19-0351