Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review
Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of thes...
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| Published in | The American journal of tropical medicine and hygiene Vol. 102; no. 5; pp. 934 - 939 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Institute of Tropical Medicine
01.05.2020
The American Society of Tropical Medicine and Hygiene |
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| Abstract | Malaria clinical studies entailing the experimental infection of healthy volunteers with
Plasmodium
parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings. |
|---|---|
| AbstractList | Malaria clinical studies entailing the experimental infection of healthy volunteers with
Plasmodium
parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings. Malaria clinical studies entailing the experimental infection of healthy volunteers with parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings. Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings.Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings. Malaria clinical studies entailing the experimental infection of healthy volunteers with Plasmodium parasites by bites from infected mosquitos, injection of cryopreserved sporozoites, or injection of blood-stage parasites provide valuable information for vaccine and drug development. Success of these studies depends on maintaining safety. In this mini-review, we discuss the safety risks and associated mitigation strategies of these three types of experimental malaria infection. We aimed to inform researchers and regulators who are currently involved in or are planning to establish experimental malaria infection studies in endemic or non-endemic settings. |
| Author | Odedra, Anand McCarthy, James S. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Authors’ addresses: Anand Odedra, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, E-mail: anand.odedra@lstmed.ac.uk. James S McCarthy, QIMR Berghofer Medical Research Institute, Brisbane, Australia, E-mail: james.mccarthy@qimrberghofer.edu.au. |
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Plasmodium
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| SubjectTerms | Animals Anopheles - parasitology Biomedical Research - methods Biomedical Research - standards Drug development Human subjects Humans Infections Malaria Malaria - parasitology Malaria - therapy Medical research Patient safety Plasmodium Research Subjects Review Risk Factors Safety |
| Title | Safety Considerations for Malaria Volunteer Infection Studies: A Mini-Review |
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