FDG-PET/CT in staging of clear cell odontogenic carcinoma

• Published in: International journal of oral and maxillofacial surgery Vol. 43; no. 11; pp. 1326 - 1329
• Main Authors: Krishnamoorthy, R, Ravi Kumar, A.S, Batstone, M
• Format: Journal Article
• Language: English
• Published: Denmark Elsevier Ltd 01.11.2014
• Subjects: Aged; Biopsy; Dentistry; Female; Fluorodeoxyglucose F18; Humans; Lymphatic Metastasis; Mandibular Neoplasms - diagnostic imaging; Mandibular Neoplasms - pathology; Mandibular Neoplasms - surgery; Maxillary Neoplasms - diagnostic imaging; Maxillary Neoplasms - pathology; Maxillary Neoplasms - surgery; Middle Aged; Multimodal Imaging; Neoplasm Staging; Odontogenic Tumors - diagnostic imaging; Odontogenic Tumors - immunology; Odontogenic Tumors - pathology; Odontogenic Tumors - surgery; Orbital Neoplasms - diagnostic imaging; Orbital Neoplasms - pathology; Orbital Neoplasms - surgery; Positron-Emission Tomography - methods; Radiopharmaceuticals; Surgery; Tomography, X-Ray Computed - methods
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/j.ijom.2014.06.008

Abstract Clear cell odontogenic carcinoma (CCOC) is a rare neoplasm; only 75 cases have been reported in the English language literature. They have a tendency for recurrence and a capacity to metastasize. There is very little known regarding the metabolic features of this tumour or the utility of fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans in the staging and follow-up of these tumours. We present two cases of CCOC with their relevant FDG-PET/CT scan findings. The first patient had primary CCOC of the mandible that was FDG-avid, and the other had recurrence of CCOC of the anterior mandible and superomedial orbit that was not FDG-avid. FDG uptake in CCOC appears to be variable. Although FDG-PET/CT is useful in other head and neck cancers and has benefits compared to other imaging modalities, further studies are needed to investigate the sensitivity of FDG-PET/CT in CCOC.