Two new quinochalcone C-glycosides from the florets of Carthamus tinctorius

• Published in: International journal of molecular sciences Vol. 15; no. 9; pp. 16760 - 16771
• Main Authors: Yue, Shijun, Tang, Yuping, Xu, Chengmei, Li, Shujiao, Zhu, Yue, Duan, Jin-Ao
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.09.2014; MDPI
• Subjects: Animals; anti-oxidative activity; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Carthamus tinctorius; Carthamus tinctorius - chemistry; Cell Line, Tumor; Chalcones - chemistry; Chalcones - isolation & purification; Chalcones - pharmacology; Flowers & plants; Flowers - chemistry; Glycosides - chemistry; Glycosides - isolation & purification; Glycosides - pharmacology; Hong hua; Hydrogen Peroxide - toxicity; hydroxysafflor yellow B; hydroxysafflor yellow C; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxidative stress; Pheochromocytoma - pathology; Pigments, Biological - chemistry; Pigments, Biological - isolation & purification; Pigments, Biological - pharmacology; quinochalcone C-glycosides; Rats; Tandem Mass Spectrometry
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms150916760

Two new quinochalcone C-glycosides, named hydroxysafflor yellow B (1) and hydroxysafflor yellow C (2), along with two known quinochalcone C-glycosides, safflomin C (3) and saffloquinoside C (4), and one known flavanone, (2R)-4',5-dihydroxyl-6, 7-di-O-β-d-glucopyranosyl flavanone (5), were isolated from the florets of Carthamus tinctorius. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these quinochalcone C-glycosides together with hydroxysafflor yellow A and anhydrosafflor yellow B were evaluated for their anti-oxidative effects against H2O2-induced cytotoxicity in cultured H9c2 cells. Among them, compound 2 exhibited significant anti-oxidative effects.