The impact of the unfolded protein response on human disease

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and secretory activities in the cell. Alterations in ER homeostasis cause accumulation of misfolded/unfolded proteins in the ER. To maintain ER homeostasis, eukaryotic cells have evolved the unfolded protein r...

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Bibliographic Details
Published inThe Journal of cell biology Vol. 197; no. 7; pp. 857 - 867
Main Authors Wang, Shiyu, Kaufman, Randal J
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 25.06.2012
The Rockefeller University Press
Subjects
Animals
Biosynthesis
Cellular biology
Disease
Endoplasmic Reticulum - chemistry
Endoplasmic Reticulum - metabolism
Eukaryotes
Homeostasis
Humans
Protein Unfolding
Proteins
Proteins - chemistry
Proteins - metabolism
Reviews
Signal Transduction
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Summary:A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and secretory activities in the cell. Alterations in ER homeostasis cause accumulation of misfolded/unfolded proteins in the ER. To maintain ER homeostasis, eukaryotic cells have evolved the unfolded protein response (UPR), an essential adaptive intracellular signaling pathway that responds to metabolic, oxidative stress, and inflammatory response pathways. The UPR has been implicated in a variety of diseases including metabolic disease, neurodegenerative disease, inflammatory disease, and cancer. Signaling components of the UPR are emerging as potential targets for intervention and treatment of human disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.201110131