Amyloid β, Lipid Metabolism, Basal Cholinergic System, and Therapeutics in Alzheimer's Disease

• Published in: International journal of molecular sciences Vol. 23; no. 20; p. 12092
• Main Authors: Campos-Peña, Victoria, Pichardo-Rojas, Pavel, Sánchez-Barbosa, Talía, Ortíz-Islas, Emma, Rodríguez-Pérez, Citlali Ekaterina, Montes, Pedro, Ramos-Palacios, Gerardo, Silva-Adaya, Daniela, Valencia-Quintana, Rafael, Cerna-Cortes, Jorge Francisco, Toral-Rios, Danira
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.10.2022; MDPI
• Subjects: Accumulation; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; amyloid β; Basal Metabolism; Brain; Cholesterol; Cholinergic Agents; cholinergic system; Cholinergic transmission; Cholinergics; Dementia; Homeostasis; Humans; Lipid Metabolism; lipid rafts; Lipids; Membranes; Memory; Metabolism; Neurodegeneration; Peptide Fragments - metabolism; Peptides; Phosphorylation; Plaques; Proteins; Receptor mechanisms; Review; Signal transduction; Sterols; Tau protein; Toxicity; lipid rafts; cholesterol; Alzheimer’s disease; amyloid β; cholinergic system
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms232012092

The presence of insoluble aggregates of amyloid β (Aβ) in the form of neuritic plaques (NPs) is one of the main features that define Alzheimer's disease. Studies have suggested that the accumulation of these peptides in the brain significantly contributes to extensive neuronal loss. Furthermore, the content and distribution of cholesterol in the membrane have been shown to have an important effect on the production and subsequent accumulation of Aβ peptides in the plasma membrane, contributing to dysfunction and neuronal death. The monomeric forms of these membrane-bound peptides undergo several conformational changes, ranging from oligomeric forms to beta-sheet structures, each presenting different levels of toxicity. Aβ peptides can be internalized by particular receptors and trigger changes from Tau phosphorylation to alterations in cognitive function, through dysfunction of the cholinergic system. The goal of this review is to summarize the current knowledge on the role of lipids in Alzheimer's disease and their relationship with the basal cholinergic system, as well as potential disease-modifying therapies.