An Overview of Ischemia-Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response

Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive ox...

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Published inThe Eurasian journal of medicine Vol. 54; no. Suppl1; pp. 62 - S65
Main Authors Güler, Mustafa Can, Tanyeli, Ayhan, Ekinci Akdemir, Fazile Nur, Eraslan, Ersen, Özbek Şebin, Saime, Güzel Erdoğan, Derya, Nacar, Tuncer
Format Journal Article
LanguageEnglish
Published Turkey AVES 01.12.2022
Atatürk University School of Medicine
Atatürk University
Subjects
Development and progression
Health aspects
Immune response
Oxidative stress
Physiology
Reperfusion injury
Review
Turkey
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Summary:Ischemia-reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia-reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia-reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia-reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (microtubu le-associated protein light chain 3, LC3) can be evaluated among these indicators.
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Cite this article as: Can Güler M, Tanyeli A, Nur Ekinci Akdemir F, Eraslan E, Özbek Şebin S, Güzel Erdoğan D, Nacar T. An overview of ischemia–reperfusion injury: Review on oxidative stress and inflammatory response. Eurasian J Med., 2022;54(Suppl. 1), S62-S65.
ISSN:1308-8734
1308-8742
1308-8742
DOI:10.5152/eurasianjmed.2022.22293