The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers
Polyphenols are capable of decreasing cancer risk. We examined the chemopreventive effects of a green tea ( ) extract, polyphenol extract (a mixture of blackberry ( ), blackcurrants ( ), and added resveratrol phytoalexin), Chinese bayberry ( ) extract, and a coffee ( ) extract on 7,12-dimethylbenz[a...
Saved in:
Published in | Cells (Basel, Switzerland) Vol. 11; no. 8; p. 1300 |
---|---|
Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
12.04.2022
MDPI |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Polyphenols are capable of decreasing cancer risk. We examined the chemopreventive effects of a green tea (
) extract, polyphenol extract (a mixture of blackberry (
), blackcurrants (
), and added resveratrol phytoalexin), Chinese bayberry (
) extract, and a coffee (
) extract on 7,12-dimethylbenz[a]anthracene (DMBA) carcinogen-increased miR-134, miR-132, miR-124-1, miR-9-3, and
gene expressions in the liver, spleen, and kidneys of CBA/Ca mice. The elevation was quenched significantly in the organs, except for miR-132 in the liver of the Chinese bayberry extract-consuming group, and miR-132 in the kidneys of the polyphenol-fed group. In the coffee extract-consuming group, only miR-9-3 and mTOR decreased significantly in the liver; also, miR-134 decreased significantly in the spleen, and, additionally, miR-124-1 decreased significantly in the kidney. Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-κB; as well as oncogenes, namely
and
. The examined chemopreventive agents, besides the obvious antioxidant and anti-inflammatory effects, mainly blocked the mentioned DMBA-activated factors and the mitogen-activated protein kinase (MAPK) as well, and, at the same time, induced
as well as
tumor suppressor genes. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
ISSN: | 2073-4409 2073-4409 |
DOI: | 10.3390/cells11081300 |