Atorvastatin decreases cellular proliferation and bone matrix expression in the hypercholesterolemic mitral valve

[...]there was significant deposition of OP within the mitral valve leaflet, which was not observed in the controls (Fig. 1, E2). The appearance of mitral valve calcifications may indicate a generalized atherosclerotic process and be predictive of coronary artery disease, suggesting that it should b...

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Published inJournal of the American College of Cardiology Vol. 45; no. 4; pp. 631 - 633
Main Authors Makkena, Babu, Salti, Hani, Subramaniam, Malayannan, Thennapan, Senthil, Bonow, Robert H., Caira, Frank, Bonow, Robert O., Spelsberg, Thomas C., Rajamannan, Nalini M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.02.2005
Elsevier Limited
Subjects
Animals
Anticholesteremic Agents - pharmacology
Anticholesteremic Agents - therapeutic use
Atherosclerosis
Atorvastatin Calcium
Bone Matrix - metabolism
Calcinosis - etiology
Calcinosis - metabolism
Calcinosis - prevention & control
Cardiology
Cardiovascular disease
Cell Division - drug effects
Cholesterol
Gene expression
Heart Valve Diseases - etiology
Heart Valve Diseases - metabolism
Heart Valve Diseases - prevention & control
Heptanoic Acids - pharmacology
Heptanoic Acids - therapeutic use
Hypercholesterolemia - complications
Hypercholesterolemia - drug therapy
Hypercholesterolemia - metabolism
Laboratory animals
Male
Mitral Valve
Pyrroles - pharmacology
Pyrroles - therapeutic use
Rabbits
Risk factors
Studies
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Summary:[...]there was significant deposition of OP within the mitral valve leaflet, which was not observed in the controls (Fig. 1, E2). The appearance of mitral valve calcifications may indicate a generalized atherosclerotic process and be predictive of coronary artery disease, suggesting that it should be included with other risk factors for coronary artery disease.
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2004.11.023