Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer

Over the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vital role in the occurrence and development of gast...

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Published inInternational journal of molecular sciences Vol. 23; no. 23; p. 15289
Main Authors Zong, Gang-Fan, Deng, Rui, Yu, Su-Yun, Wang, Ai-Yun, Wei, Zhong-Hong, Zhao, Yang, Lu, Yin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.12.2022
MDPI
Subjects
Apoptosis
Cancer therapies
Cell growth
Channels
Cold
Colon
Gastric cancer
Humans
Insects
ion channel
Ligands
Medical prognosis
Nervous system
Patients
Physiology
Polyamines
Precision medicine
Proteins
Review
Stomach Neoplasms - drug therapy
Stomach Neoplasms - genetics
temperature
therapeutic target
Transient Receptor Potential Channels - metabolism
Transient receptor potential proteins
TRP
Trp protein
Tumors
temperature
therapeutic target
TRP
gastric cancer
ion channel
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Summary:Over the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vital role in the occurrence and development of gastric cancer (GC). Accordingly, thermo-TRPs constitute a major pharmacological target, and the elucidation of the mechanisms underlying their response to physiological stimuli or drugs is key for notable advances in GC treatment. Therefore, this paper summarizes the existing literature about thermo-TRP protein expression changes that are linked to the incidence and progression of GC. The review also discusses the implication of such association to pathology and cell physiology and identifies potential thermo-TRP protein targets for diagnosis and treatment of GC.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232315289