Anti-inflammatory Effect of Bumblebee Alcohol Extracts in CFA-Induced Rat Edema

• Published in: Toxicological research (Seoul) Vol. 28; no. 4; pp. 249 - 253
• Main Authors: Ahn, M.Y., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Han, J.W., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Yoon, H.J., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Hwang, J.S., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea, Young, Y.E., National Academy of Agricultural Science, RDA, Suwon, Republic of Korea
• Format: Journal Article
• Language: English
• Published: Singapore 한국독성학회 01.12.2012; The Korean Society of Toxicology
• Subjects: Bumblebee alcohol extract; EDEMA; OEDEMA; OEDEME; 예방의학; Edema; Bumblebee alcohol extract
• ISSN: 1976-8257; 2234-2753
• DOI: 10.5487/TR.2012.28.4.249

In this study, we prepared alcohol extracts of the larva, pupa, queen, and cocoon (clony) of B. ignitus, B. terrestris, and B. h. sapporoensis, and tested the anti-inflammatory activity of the extracts by using a rat model of adjuvant-induced edema. The extracts derived from the queen of B. ignitus, the queen of B. terrestris, and the cocoon of B. ignitus decreased hind paw edema after 1 day of i.p. administration. These extracts also induced vasorelaxation and NO production in calf pulmonary artery endothelial cells. These results suggest that bumblebee alcohol extracts has anti-inflammatory and vasorelaxant properties.