Relationship of Neutrophil-to-Lymphocyte Ratio with Aortic Stiffness in Type 1 Diabetes Mellitus

• Published in: Canadian journal of diabetes Vol. 39; no. 4; pp. 317 - 321
• Main Authors: Ayhan, Hüseyin, MD, Kasapkara, Hacı Ahmet, MD, Aslan, Abdullah Nabi, MD, Durmaz, Tahir, MD, Keleş, Telat, MD, Akçay, Murat, MD, Akar Bayram, Nihal, MD, Baştuğ, Serdal, MD, Bilen, Emine, MD, Sarı, Cenk, MD, Bozkurt, Engin, MD
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Inc 01.08.2015
• Subjects: Adult; aortic stiffness; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - diagnosis; diabète sucré de type 1; echocardiography; Endocrinology & Metabolism; Female; Humans; inflammation; Lymphocytes - metabolism; Male; neutrophil to lymphocyte ratio; Neutrophils - metabolism; Other; rapport neutrophiles/lymphocytes; rigidité aortique; type 1 diabetes mellitus; Vascular Stiffness - physiology; Young Adult; échocardiographie; type 1 diabetes mellitus; aortic stiffness; rapport neutrophiles/lymphocytes; inflammation; echocardiography; rigidité aortique; neutrophil to lymphocyte ratio; échocardiographie; diabète sucré de type 1
• ISSN: 1499-2671; 2352-3840
• DOI: 10.1016/j.jcjd.2015.01.004

Abstract Objectives Emerging evidence suggests that the neutrophil-to-lymphocyte ratio (NLR) may be a useful marker of inflammation and aortic stiffness. Markers of inflammation and aortic stiffness are both indicators of cardiovascular events. We, therefore, investigated whether the NLR is associated with aortic stiffness in patients with type 1 diabetes mellitus. Methods We examined the relationship of the NLR to aortic stiffness in 76 people with type 1 diabetes and 36 healthy controls. Results The NLRs in the group with type 1 diabetes were higher than in the controls (2.33±0.95 vs. 1.80±0.68, respectively; p=0.003). Aortic strain and aortic distensibility, the parameters of aortic stiffness, measured noninvasively by the help of echocardiography, were significantly decreased in the patient group compared to controls (8.0%±1.5% vs. 13.1%±3.3 %; p<0.001 and 3.6±1.1 cm2 .dyn−1 .10−3 vs. 6.0±2.1 cm2 .dyn−1 .10−3 ; p<0.001, respectively). There were negative correlations between NLR and distensibility (r: −0.40; p<0.001) and strain (r: −0.57; p<0.001) in patients with type 1 diabetes. Conclusions We have demonstrated that there is a significant negative correlation between the NLR and markers of aortic stiffness in patients with type 1 diabetes, indicating a potential association between inflammation and arterial stiffness. Accordingly, a higher NLR may be a useful additional measure in determining the cardiovascular risks of patients with type 1 diabetes in our clinical practice.