Mesenchymal Stem Cell Therapy in Diabetic Cardiomyopathy

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 2; p. 240
• Main Authors: da Silva, Jaqueline S, Gonçalves, Renata G J, Vasques, Juliana F, Rocha, Bruna S, Nascimento-Carlos, Bianca, Montagnoli, Tadeu L, Mendez-Otero, Rosália, de Sá, Mauro P L, Zapata-Sudo, Gisele
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.01.2022; MDPI
• Subjects: Age; Animals; Apoptosis; cardiac remodeling; Cardiomyocytes; Cardiomyopathy; Cardiovascular disease; Cell adhesion & migration; Cell death; Cell survival; Cell therapy; Clinical Trials as Topic; Collagen; Cytochrome; Cytokines; Diabetes; Diabetes mellitus; Diabetic Cardiomyopathies - genetics; Diabetic Cardiomyopathies - physiopathology; Diabetic Cardiomyopathies - therapy; diabetic cardiomyopathy; Ejection fraction; Epigenesis, Genetic; Extracellular matrix; Fibroblasts; Fibrosis; Glucose; Growth factors; Heart failure; Humans; Hyperglycemia; Inflammation; Kinases; Lipid peroxidation; Lipids; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; mesenchymal stromal cells; Metabolism; Models, Biological; Oxidative stress; pro-inflammatory cytokines; Proteins; Review; Stem cells; Vascular Remodeling; pro-inflammatory cytokines; cardiac remodeling; mesenchymal stromal cells; diabetes mellitus; fibrosis; diabetic cardiomyopathy; oxidative stress
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells11020240

The incidence and prevalence of diabetes mellitus (DM) are increasing worldwide, and the resulting cardiac complications are the leading cause of death. Among these complications is diabetes-induced cardiomyopathy (DCM), which is the consequence of a pro-inflammatory condition, oxidative stress and fibrosis caused by hyperglycemia. Cardiac remodeling will lead to an imbalance in cell survival and death, which can promote cardiac dysfunction. Since the conventional treatment of DM generally does not address the prevention of cardiac remodeling, it is important to develop new alternatives for the treatment of cardiovascular complications induced by DM. Thus, therapy with mesenchymal stem cells has been shown to be a promising approach for the prevention of DCM because of their anti-apoptotic, anti-fibrotic and anti-inflammatory effects, which could improve cardiac function in patients with DM.