Investigating adverse events following immunisation with pneumococcal polysaccharide vaccine using electronic General Practice data

• Published in: Vaccine Vol. 35; no. 11; pp. 1524 - 1529
• Main Authors: Trinh, L, Macartney, K, McIntyre, P, Chiu, C, Dey, A, Menzies, R
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 13.03.2017; Elsevier Limited
• Subjects: Adolescent; Adult; Adverse events following immunisation; Age; Aged; Aged, 80 and over; Allergy and Immunology; Australia; Automatic Data Processing; Clinics; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; Electronic medical records; Female; Gender; General Practice; Humans; Immunization; Influenza; Male; Middle Aged; Patients; Pneumococcal polysaccharide vaccine; Pneumococcal Vaccines - administration & dosage; Pneumococcal Vaccines - adverse effects; Primary health care; Public health surveillance; Retrospective Studies; Streptococcus pneumoniae; Vaccines; Young Adult; Australia; GPRN; Primary health care; GP; Electronic medical records; adverse events following immunisation; TGA; Therapeutic Goods Administration; General Practitioner; Pneumococcal polysaccharide vaccine; Public health surveillance; 23vPPV; AEFI; General Practice Research Network; 23-valent pneumococcal polysaccharide vaccine; Adverse events following immunisation
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2017.01.063

Highlights • 23vPPV booster recommendations were changed in 2011 following an increase in AEFI reports. • A post-hoc analysis of electronic data from 250 General Practices was conducted to verify the signal. • It was 10-15 times more sensitive than passive reporting, enough to detect a 3-fold increase. • The original apparent signal appears to have been an artefact. • This data source has substantial potential, but would need to be larger and available in real time.