Serum Intact-Parathyroid Hormone Level following Total Knee Arthroplasty

Purpose. To evaluate short-term parathyroid hormone (PTH) secretion following total knee arthroplasty (TKA). Methods. 119 Caucasian postmenopausal women aged 49 to 81 (mean, 69.8) years who underwent TKA for end-stage knee osteoarthritis were included. Serum levels of intact-PTH, calcium, phosphorus...

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Published inJournal of orthopaedic surgery (Hong Kong) Vol. 20; no. 1; pp. 27 - 31
Main Authors Papavasiliou, Kyriakos A, Nikopoulou, Aggeliki, Kenanidis, Eustathios I, Potoupnis, Michael E, Kyrkos, Margaritis J, Sayegh, Fares E, Kapetanos, George A
Format Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.04.2012
Sage Publications Ltd
SAGE Publishing
Subjects
Aged
Aged, 80 and over
Apoptosis
Arthritis
Arthroplasty, Replacement, Knee
Bone density
Bones
Female
Homeostasis
Humans
Joint surgery
Knee
Middle Aged
Parathyroid Hormone - blood
Prospective Studies
Prostheses
Studies
Transplants & implants
parathyroid hormone
osteoporosis, postmenopausal
arthroplasty, replacement, knee
osteoarthritis, knee
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Summary:Purpose. To evaluate short-term parathyroid hormone (PTH) secretion following total knee arthroplasty (TKA). Methods. 119 Caucasian postmenopausal women aged 49 to 81 (mean, 69.8) years who underwent TKA for end-stage knee osteoarthritis were included. Serum levels of intact-PTH, calcium, phosphorus, and creatinine were evaluated pre- and post-operatively (on days −1 and 7). Creatinine clearance was also calculated. Results. In 67 of the patients, serum intact-PTH levels decreased after TKA; this sample proportion was not significant (p=0.82). In 16 of the patients, such levels elevated abnormally (above normal range). In the remaining 36 patients, such levels elevated within the normal range. Therefore, the mean serum intact-PTH level of all patients increased slightly after TKA (45.4 vs. 45.3, p=0.162). The serum intact-PTH level did not correlate to body weight (r=–0.045, p=0.624), patient age (r=–0.061, p=0.508), serum creatinine level (r=0.084, p=0.366), and clearance of creatinine (r=–0.037, p=0.692). Conclusion. In most postmenopausal women, the serum intact-PTH level decreased moderately following TKA, but in some, the level was abnormally elevated. This may interfere the prosthesis incorporation process.
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ISSN:1022-5536
2309-4990
DOI:10.1177/230949901202000106