A PET/CT volumetric parameter predicts prognosis of non-small cell lung cancer treated using preoperative chemoradiotherapy and surgery: A retrospective case series study

• Published in: Molecular and clinical oncology Vol. 14; no. 4; p. 73
• Main Authors: Katsui, Kuniaki, Ogata, Takeshi, Tada, Akihiro, Watanabe, Kenta, Yoshio, Kotaro, Kuroda, Masahiro, Kiura, Katsuyuki, Hiraki, Takao, Toyooka, Shinichi, Kanazawa, Susumu
• Format: Journal Article
• Language: English
• Published: England Spandidos Publications UK Ltd 01.04.2021; D.A. Spandidos
• Subjects: Cardiac arrhythmia; Chemotherapy; Lung cancer; Lymphatic system; Medical imaging; Medical prognosis; Metabolism; Metastasis; Neurological disorders; Oncology; Patients; Pneumonia; Pulmonary arteries; Radiation therapy; Statistical analysis; Surgery; Thrombosis; Tomography; non-small cell lung cancer; Δtotal lesion glycolysis; positron emission tomography; preoperative concurrent chemoradiotherapy
• ISSN: 2049-9450; 2049-9469
• DOI: 10.3892/mco.2021.2235

The purpose of the present study was to clarify whether positron emission tomography/computed tomography (PET/CT) volumetric parameters were prognostic predictors of non-small cell lung cancer (NSCLC) treatment in patients who had undergone preoperative concurrent chemoradiotherapy (CCRT) and surgery. In the present study, retrospectively surveyed the data of patients with NSCLC who underwent preoperative CCRT and surgery at Okayama University Hospital (Okayama, Japan) between April 2006 and March 2018. The maximum standardized uptake value (SUV ) and volumetric parameters, including metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were calculated using PET/CT and the percentage decrease (Δ) in each parameter value post-CCRT. The SUV threshold for defining MTV was set at 2.5. Furthermore, the association between survival and PET parameter values was analyzed. A total of 52 patients were included in the present study. The median follow-up period was 50.65 months. In univariate analysis, ΔTLG was identified to be a significant predictor of progression-free survival (PFS; P=0.03). The 5-year PFS rates were 48.6 and 76.6% for patients with low ΔTLG and high ΔTLG, respectively. High ΔTLG was indicative of a higher overall survival rate (P=0.08). The present results suggest that ΔTLG calculated using PET/CT is a prognostic predictor of NSCLC treated using preoperative CCRT and surgery, and may help physicians determine treatment strategies.