Oncogenic Mutations of PIK3CA in Human Cancers

Phosphatidylinositol 3-kinases (PI3Ks) are important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in human cancers, we recently analyzed the sequences of the PI3K gene family and discovered that one member, the PIK3CA gene encoding the p110? catalytic subunit,...

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Bibliographic Details
Published inCell cycle (Georgetown, Tex.) Vol. 3; no. 10; pp. 1221 - 1224
Main Authors Samuels, Yardena, Velculescu, Victor E.
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.10.2004
Subjects
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Class I Phosphatidylinositol 3-Kinases
Cycle
Humans
Landes
Mutation - genetics
Neoplasms - diagnosis
Neoplasms - genetics
Neoplasms - therapy
Organogenesis
Phosphatidylinositol 3-Kinases - chemistry
Phosphatidylinositol 3-Kinases - genetics
Phosphatidylinositol 3-Kinases - metabolism
Proteins
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Summary:Phosphatidylinositol 3-kinases (PI3Ks) are important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in human cancers, we recently analyzed the sequences of the PI3K gene family and discovered that one member, the PIK3CA gene encoding the p110? catalytic subunit, was frequently mutated in cancers of the colon, breast, brain and lung. The majority of mutations clustered near two positions within the PI3K helical or catalytic domains and at least one hotspot mutation appeared to increase kinase activity. PIK3CA represents one of the most highly mutated oncogenes identified in human cancers and may be a useful diagnostic and therapeutic target.
Bibliography:ObjectType-Article-1
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ISSN:1538-4101
1551-4005
DOI:10.4161/cc.3.10.1164