Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity

• Published in: European journal of nutrition Vol. 57; no. 3; pp. 965 - 979
• Main Authors: Hira, Tohru, Suto, Ryoya, Kishimoto, Yuka, Kanahori, Sumiko, Hara, Hiroshi
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2018; Springer Nature B.V
• Subjects: Adipose tissue; Cecum; Chemistry; Chemistry and Materials Science; Diet; Energy intake; Fatty acids; Feeding; Food intolerance; Fructooligosaccharides; Glucagon; Glucagon-like peptide 1; Glucose; Glucose tolerance; High fat diet; Large intestine; Maltodextrin; Nutrition; Original Contribution; Physiology; Propionic acid; Rodents; Secretion; Sucrose; Appetite; Glucagon-like peptide-1; High-fat and high-sucrose diet; Adiposity; Resistant maltodextrin; Fructooligosaccharides
• ISSN: 1436-6207; 1436-6215
• DOI: 10.1007/s00394-017-1381-7

Purpose Increasing secretion and production of glucagon-like peptide-1 (GLP-1) by continuous ingestion of certain food components has been expected to prevent glucose intolerance and obesity. In this study, we examined whether a physiological dose (5% weight in diet) of digestion-resistant maltodextrin (RMD) has a GLP-1-promoting effect in rats fed a high-fat and high-sucrose (HFS) diet. Methods Rats were fed a control diet or the HFS (30% fat, 40% sucrose wt/wt) diet supplemented with 5% RMD or fructooligosaccharides (FOS) for 8 weeks or for 8 days in separated experiments. Glucose tolerance, energy intake, plasma and tissue GLP-1 concentrations, and cecal short-chain fatty acids concentrations were assessed. Results After 4 weeks of feeding, HFS-fed rats had significantly higher glycemic response to oral glucose than control rats, but rats fed HFS + RMD/FOS did not (approx. 50% reduction vs HFS rats). HFS + RMD/FOS-fed rats had higher GLP-1 responses (~twofold) to oral glucose, than control rats. After 8 weeks, visceral adipose tissue weight was significantly higher in HFS-fed rats than control rats, while HFS + RMD/FOS rats had a trend of reduced gain (~50%) of the tissue weight. GLP-1 contents and luminal propionate concentrations in the large intestine increased (>twofold) by adding RMD/FOS to HFS. Eight days feeding of RMD/FOS-supplemented diets reduced energy intake (~10%) and enhanced cecal GLP-1 production (~twofold), compared to HFS diet. Conclusions The physiological dose of a prebiotic fiber promptly (within 8 days) promotes GLP-1 production in rats fed an obesogenic diet, which would help to prevent excess energy intake and fat accumulation.