Dual (pH- and ROS-) Responsive Antibacterial MXene-Based Nanocarrier for Drug Delivery

• Published in: International journal of molecular sciences Vol. 23; no. 23; p. 14925
• Main Authors: Zhang, Wei-Jin, Li, Shuwei, Yan, Yong-Zhu, Park, Sung Soo, Mohan, Anandhu, Chung, Ildoo, Ahn, Suk-Kyun, Kim, Jung Rae, Ha, Chang-Sik
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.11.2022; MDPI
• Subjects: Aluminum; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Aqueous solutions; Atomic force microscopy; Blood vessels; Cancer; Carbon; Chemotherapy; Doxorubicin; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug carriers; Drug delivery; Drug Delivery Systems; Drug Liberation; Drugs; Electron microscopy; Escherichia coli; Etching; Hydrogen-Ion Concentration; Infrared spectroscopy; Magnetic resonance spectroscopy; Medical research; MXene; MXenes; NMR; NMR spectroscopy; Nuclear magnetic resonance; pH-responsive; Photoelectron spectroscopy; Photoelectrons; ROS-responsive; Scanning electron microscopy; Spectroscopy, Fourier Transform Infrared; Spectrum analysis; Thickness; Transmission electron microscopy; Vibration; X-ray diffraction; X-ray spectroscopy; Zeta potential; antibacterial activity; ROS-responsive; doxorubicin; drug delivery; pH-responsive; MXene
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms232314925

In this study, a novel MXene (Ti C T )-based nanocarrier was developed for drug delivery. MXene nanosheets were functionalized with 3, 3'-diselanediyldipropionic acid (DSeDPA), followed by grafting doxorubicin (DOX) as a model drug to the surface of functionalized MXene nanosheets (MXene-Se-DOX). The nanosheets were characterized using scanning electron microscopy, atomic force microscopy (AFM), transmission electron microscopy, energy-dispersive X-ray spectroscopy (EDX), nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and zeta potential techniques. The drug-loading capacity (17.95%) and encapsulation efficiency (41.66%) were determined using ultraviolet-visible spectroscopy. The lateral size and thickness of the MXene nanosheets measured using AFM were 200 nm and 1.5 nm, respectively. The drug release behavior of the MXene-Se-DOX nanosheets was evaluated under different medium conditions, and the nanosheets demonstrated outstanding dual (reactive oxygen species (ROS)- and pH-) responsive properties. Furthermore, the MXene-Se-DOX nanosheets exhibited excellent antibacterial activity against both Gram-negative and Gram-positive .