Thermochemical Aspects of Water/n-Octanol Partitioning of Some Local Anaesthetic Agents

The water/n-octanol partitioning thermodynamic parameters of some local anaesthesic agents are determined through a calorimetric estimation of the enthalpies of transfer. Partitionings are entropy-driven. Although no single mechanism of transfer can be ascribed, the mechanisms seem identical for eac...

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 42; no. 8; pp. 1553 - 1555
Main Authors BURGOT, Gwenola, BURGOT, Jean-Louis
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1994
Maruzen
Japan Science and Technology Agency
Subjects
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
enthalpy
entropy
hydrophobicity
l-octanol/water
local anaesthetic agent
Medical sciences
Neuropharmacology
partition property
Pharmacology. Drug treatments
thermometric titrimetry
Local anesthetic
Water
Ethanol
Enthalpy
Partition coefficient
Entropy
Thermodynamic properties
Physicochemical properties
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Summary:The water/n-octanol partitioning thermodynamic parameters of some local anaesthesic agents are determined through a calorimetric estimation of the enthalpies of transfer. Partitionings are entropy-driven. Although no single mechanism of transfer can be ascribed, the mechanisms seem identical for each subfamily of the same kind of structure.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.42.1553