Essential Oils from Annonaceae Species from Brazil: A Systematic Review of Their Phytochemistry, and Biological Activities

• Published in: International journal of molecular sciences Vol. 22; no. 22; p. 12140
• Main Authors: Cascaes, Márcia Moraes, Carneiro, Odirleny Dos Santos, Nascimento, Lidiane Diniz do, de Moraes, Ângelo Antônio Barbosa, de Oliveira, Mozaniel Santana, Cruz, Jorddy Neves, Guilhon, Giselle Maria Skelding Pinheiro, Andrade, Eloisa Helena de Aguiar
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.11.2021; MDPI
• Subjects: Annonaceae; Annonaceae - chemistry; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - therapeutic use; Antiinfectives and antibacterials; Antimalarial agents; Antioxidants; Antiproliferatives; applications; Bicyclogermacrene; Biodiversity; Biological activity; Biological effects; Brazil; Brazilian species; Caryophyllene; Caryophyllene oxide; Chemical composition; Composition effects; Cosmetics; Cytotoxicity; essential oil; Essential oils; Flowers & plants; Food products; Germacrene; Herbal medicine; Humans; Hydrocarbons; Inflammation; Limonene; Malaria; Multiculturalism & pluralism; Natural products; Odors; Oils & fats; Oils, Volatile - chemistry; Oils, Volatile - therapeutic use; Phytochemicals - chemistry; Plant Leaves - chemistry; Polycyclic Sesquiterpenes - chemistry; Raw materials; Review; Rheumatism; Seeds; Sesquiterpenes - chemistry; Sesquiterpenes, Germacrane - chemistry; Spathulenol; Systematic review; Tropical diseases; Brazil; Atlantic Forest; natural products; Brazilian species; essential oil; applications
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms222212140

The present work involves a systematic review of the chemical composition and biological effects of essential oils from the Annonaceae species collected in Brazil from 2011 to 2021. Annonaceae is one of the most important botanical families in Brazil, as some species have economic value in the market as local and international fruit. In addition, the species have useful applications in several areas-for instance, as raw materials for use in cosmetics and perfumery and as medicinal plants. In folk medicine, species such as L. and A. St.-Hil. are used to treat diseases such as rheumatism and malaria. The species of Annonaceae are an important source of essential oils and are rich in compounds belonging to the classes of mono and sesquiterpenes; of these compounds, α-pinene, β-pinene, limonene, ( )-caryophyllene, bicyclogermacrene, caryophyllene oxide, germacrene D, spathulenol, and β-elemene are the most abundant. The antimicrobial, anti-inflammatory, antileishmania, antioxidant, antiproliferative, cytotoxic, larvicidal, trypanocidal, and antimalarial activities of essential oils from the Annonaceae species in Brazil have been described in previous research, with the most studies on this topic being related to their antiproliferative or cytotoxic activities. In some studies, it was observed that the biological activity reported for these essential oils was superior to that of drugs available on the market, as is the case of the essential oil of the species (Aubl.) R. A. Howard., which showed a trypanocidal effect that was 34 times stronger than that of the reference drug benznidazol.