Veterinary-based biopharmaceuticals

• Published in: Trends in biotechnology (Regular ed.) Vol. 30; no. 12; pp. 615 - 620
• Main Authors: Ryan, Michael P, Walsh, Gary
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2012; Elsevier Limited
• Subjects: Animals; Aquaculture; Biological Products - standards; Dairy cattle; Deoxyribonucleic acid; DNA; E coli; Humans; Immunization; Insulin; Internal Medicine; Melanoma; Pharmaceutical industry; Poultry; Recombinant Proteins - standards; Salmon; Vaccines; Vaccines - standards; Veterinary Drugs
• ISSN: 0167-7799; 1879-3096
• DOI: 10.1016/j.tibtech.2012.08.005

Between them, these regions represent almost 80% of the global animal healthcare market (http://www.dolcera.com/wiki/index.php?tiitle=Veterinary_Vaccines_Market_Report). [...]comparison of veterinary products to those destined for human application reveals some interesting differences in scientific, technological, and commercial terms. DNA vaccines and other gene therapy products Although the potential of DNA-based therapies in human medicine remains to be realized, four such products have thus far gained approval for veterinary purposes.\n gallisepticum 2006 (USA, USDA, Ceva) Vectormune FP-N HN and F antigens of NDV expressed on an FPV vector Chicken/turkey Immunization against NDV 2006 (USA, USDA, Ceva) DNA-Based Vaccines Apex-IHN DNA vaccine -plasmid containing the glycoprotein gene of IHN virus Farmed salmon Immunization against IHN virus 2005 (Canada, Health Canada, Novartis Aqua Health) Oncept DNA vaccine -plasmid containing a human tyrosinase gene Dog Canine malignant melanoma vaccine 2010 (USA, USDA, Merial) West Nile Innovator DNA vaccine -plasmid DNA containing the PreM-E gene of WNV Horse Immunization against WNV 2005 (USA, USDA, Fort Dodge Animal Health) Non-vaccine-based products LifeTide SW 5 Gene therapy product; DNA plasmid containing porcine growth-hormone-releasing hormone gene Piglet Growth-hormone-releasing hormone DNA therapy for pigs to increase the number of piglets weaned 2008 (Australia, APVMA,VGX Animal Health) Posilac Sometribove zinc; recombinant bovine somatotropin produced in E. coli Dairy cow Improve milk productivity 1994 (USA, FDA, Elanco Animal Health) Prozinc Protamine zinc insulin; recombinant human insulin produced in E. coli Cat Treatment of feline diabetes mellitus 2009 (USA, FDA, Boehringer Ingelheim Vetmedica) TruScient Recombinant human dibotermin α produced in a CHO cell line Dog Treatment of bone fractures 2011 (EU, EMA, Pfizer) Vibragen Omega Recombinant feline interferon omega produced in silkworms Cat Reduce mortality and clinical signs of canine parvovirusis, treatment of FIV 2001 (EU, EMA, Virbac SA) Table 1 Veterinary biopharmaceuticals approved thus far in the EU and/or the USA.