Anti-mitotic therapies in cancer
Tischer and Gergely review the cell biology behind microtubule poisons and their clinical use in cancer patients.
Saved in:
| Published in | The Journal of cell biology Vol. 218; no. 1; pp. 10 - 11 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Rockefeller University Press
07.01.2019
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Tischer and Gergely review the cell biology behind microtubule poisons and their clinical use in cancer patients. |
|---|---|
| AbstractList | Tischer and Gergely review the cell biology behind microtubule poisons and their clinical use in cancer patients. Tischer and Gergely discuss the anti-mitotic therapies in cancer. Chronic cellular proliferation is a hallmark of cancer, and therefore therapies targeting key pathways that drive and execute cell division have been a major research goal. The somatic cell division cycle culminates in mitosis, when the microtubule (MT)-based mitotic spindle captures, aligns, and then equally distributes chromosomes into daughter cells. Polo-like kinase 1 (PLK1) and Aurora kinases (AurA and AurB) play pleiotropic roles during mitosis; they are important for mitotic entry and exit, spindle assembly, and also the capture, alignment, and segregation of chromosomes. |
| Author | Tischer, Julia Gergely, Fanni |
| AuthorAffiliation | Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK |
| AuthorAffiliation_xml | – name: Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK |
| Author_xml | – sequence: 1 givenname: Julia surname: Tischer fullname: Tischer, Julia organization: Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK – sequence: 2 givenname: Fanni orcidid: 0000-0002-2441-8095 surname: Gergely fullname: Gergely, Fanni email: fanni.gergely@cruk.cam.ac.uk organization: Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK fanni.gergely@cruk.cam.ac.uk |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30545842$$D View this record in MEDLINE/PubMed |
| BookMark | eNpVkEtLAzEQgINU7EOPXmXBc-rktZu9CKX4goIXPYdsMmtT2mzNbgX_vVtai57mMB_fDN-YDGITkZBrBlMGWtytXDXlwDRoKIozMmJKAtVMwoCMADijpeJqSMZtuwIAWUhxQYYClFRa8hHJZrELdBO6pgsu65aY7DZgm4WYORsdpktyXtt1i1fHOSHvjw9v82e6eH16mc8W1EnNOtrLSkQlnC2td4Llnude-LKqLSpWFwiMV3VdYQ7ei9wpzL0sUEmtCyg1ExNyf_Bud9UGvcPYJbs22xQ2Nn2bxgbzfxPD0nw0XyYXTCpV9ILboyA1nztsO7Nqdin2PxvO8pJLBWxP0QPlUtO2CevTBQZmH9T0Qc0paM_f_H3rRP8WFD_TknJ2 |
| CitedBy_id | crossref_primary_10_1016_j_isci_2023_107681 crossref_primary_10_3390_futurepharmacol2030015 crossref_primary_10_1038_s41419_021_03919_x crossref_primary_10_1167_iovs_64_4_23 crossref_primary_10_1002_ddr_22016 crossref_primary_10_1002_slct_202003322 crossref_primary_10_1038_s41467_021_21447_2 crossref_primary_10_1080_07391102_2024_2314752 crossref_primary_10_1002_jnr_24428 crossref_primary_10_1007_s10354_022_00966_7 crossref_primary_10_3390_cancers15133308 crossref_primary_10_3389_fonc_2019_01301 crossref_primary_10_3389_fonc_2021_761901 crossref_primary_10_1016_j_tranon_2023_101819 crossref_primary_10_1038_s41419_021_03434_z crossref_primary_10_1038_s41580_021_00404_3 crossref_primary_10_2174_0929867326666191016113631 crossref_primary_10_1016_j_canlet_2021_11_018 crossref_primary_10_7717_peerj_13508 crossref_primary_10_3389_fcell_2020_00388 crossref_primary_10_3390_ijms232012104 crossref_primary_10_2144_fsoa_2021_0116 crossref_primary_10_3390_diagnostics12020470 crossref_primary_10_1038_s41467_023_41840_3 crossref_primary_10_1039_D1DT03553C crossref_primary_10_1016_j_ejmech_2021_113288 crossref_primary_10_1242_jcs_255802 crossref_primary_10_3389_fcell_2021_767221 crossref_primary_10_1021_acsmedchemlett_2c00098 crossref_primary_10_1016_j_actbio_2022_04_002 crossref_primary_10_1016_j_heliyon_2024_e27959 crossref_primary_10_1039_D1MD00392E crossref_primary_10_1039_D3RA06790D crossref_primary_10_3390_md17100569 crossref_primary_10_1021_jacs_9b12782 crossref_primary_10_1002_slct_202004088 crossref_primary_10_1038_s41419_022_05312_8 crossref_primary_10_1080_17425247_2021_1825377 crossref_primary_10_1126_science_add9528 crossref_primary_10_3390_molecules27154920 crossref_primary_10_1021_acs_inorgchem_0c00957 crossref_primary_10_1038_s41467_021_23965_5 crossref_primary_10_1038_s41389_023_00458_2 crossref_primary_10_1083_jcb_202311140 crossref_primary_10_1002_cbic_202300178 crossref_primary_10_1038_s41419_023_05946_2 crossref_primary_10_3389_fmolb_2024_1328077 crossref_primary_10_1084_jem_20202669 |
| Cites_doi | 10.1242/jcs.039719 10.1016/j.pharmthera.2017.02.007 10.1158/1535-7163.MCT-15-0897 10.1016/j.molcel.2015.11.006 10.1038/nrc2803 10.1016/j.ejmech.2017.08.045 10.1038/nrd3253 10.1016/j.ijpharm.2017.05.016 10.1530/ERC-17-0003 10.1038/nrclinonc.2010.228 |
| ContentType | Journal Article |
| Copyright | Copyright Rockefeller University Press Jan 2019 2018 Tischer and Gergely 2018 |
| Copyright_xml | – notice: Copyright Rockefeller University Press Jan 2019 – notice: 2018 Tischer and Gergely 2018 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QL 7QP 7QR 7TK 7TM 7U9 8FD C1K FR3 H94 M7N P64 RC3 5PM |
| DOI | 10.1083/jcb.201808077 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts Genetics Abstracts PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Virology and AIDS Abstracts Technology Research Database Nucleic Acids Abstracts Neurosciences Abstracts Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management Genetics Abstracts Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Chemoreception Abstracts Engineering Research Database Calcium & Calcified Tissue Abstracts |
| DatabaseTitleList | CrossRef Virology and AIDS Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| DocumentTitleAlternate | Anti-mitotic therapies in cancer |
| EISSN | 1540-8140 |
| EndPage | 11 |
| ExternalDocumentID | 10_1083_jcb_201808077 30545842 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Review |
| GrantInformation_xml | – fundername: Cancer Research UK grantid: CRUK/A17043 – fundername: ; grantid: HA-8069/1-1 – fundername: ; grantid: CRUK/A17043 |
| GroupedDBID | --- -DZ -~X .55 123 18M 29K 2WC 34G 36B 39C 4.4 53G 85S ABDNZ ABOCM ABPPZ ABRJW ABZEH ACGFO ACGOD ACIWK ACKOT ACNCT ACPRK ADBBV AEILP AENEX AFOSN AFRAH ALMA_UNASSIGNED_HOLDINGS AOIJS B-7 BAWUL BKOMP BTFSW C45 CGR CS3 CUY CVF D-I D0L DIK DU5 E3Z EBS ECM EIF EJD EMB F5P F9R FRP GX1 H13 HF~ HYE IH2 JZ9 KQ8 N9A NHB NPM O5R O5S OK1 P2P PQQKQ R.V RHF RHI RNS RPM RXW SJN TAE TN5 TR2 TRP TWZ UBX UHB UKR UPT VQA W8F WH7 WOQ X7M YKV YNH YOC YQT YSK YWH YZZ ZCA ~KM AAYXX CITATION 7QL 7QP 7QR 7TK 7TM 7U9 8FD C1K FR3 H94 M7N P64 RC3 5PM |
| ID | FETCH-LOGICAL-c481t-8429ee53ca9adc316d26d3d9bfae51f7e012bffbe60dd36c5e6d47e5488709813 |
| ISSN | 0021-9525 |
| IngestDate | Tue Sep 17 21:07:02 EDT 2024 Thu Oct 10 16:26:33 EDT 2024 Thu Nov 21 21:09:41 EST 2024 Sat Nov 02 12:31:10 EDT 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c481t-8429ee53ca9adc316d26d3d9bfae51f7e012bffbe60dd36c5e6d47e5488709813 |
| ORCID | 0000-0002-2441-8095 |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC6314557 |
| PMID | 30545842 |
| PQID | 2169245017 |
| PQPubID | 48855 |
| PageCount | 2 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6314557 proquest_journals_2169245017 crossref_primary_10_1083_jcb_201808077 pubmed_primary_30545842 |
| PublicationCentury | 2000 |
| PublicationDate | 20190107 |
| PublicationDateYYYYMMDD | 2019-01-07 |
| PublicationDate_xml | – month: 1 year: 2019 text: 20190107 day: 7 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: New York |
| PublicationTitle | The Journal of cell biology |
| PublicationTitleAlternate | J Cell Biol |
| PublicationYear | 2019 |
| Publisher | Rockefeller University Press |
| Publisher_xml | – name: Rockefeller University Press |
| References | Komlodi-Pasztor (2023072400195009300_bib10) 2011; 8 Kavallaris (2023072400195009300_bib3) 2010; 10 Borisa (2023072400195009300_bib8) 2017; 140 Gutteridge (2023072400195009300_bib9) 2016; 15 Gascoigne (2023072400195009300_bib4) 2009; 122 Shi (2023072400195009300_bib5) 2017; 24 Dominguez-Brauer (2023072400195009300_bib7) 2015; 60 Dumontet (2023072400195009300_bib1) 2010; 9 Penna (2023072400195009300_bib6) 2017; 173 Bernabeu (2023072400195009300_bib2) 2017; 526 |
| References_xml | – volume: 122 start-page: 2579 year: 2009 ident: 2023072400195009300_bib4 publication-title: J. Cell Sci. doi: 10.1242/jcs.039719 contributor: fullname: Gascoigne – volume: 173 start-page: 67 year: 2017 ident: 2023072400195009300_bib6 publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2017.02.007 contributor: fullname: Penna – volume: 15 start-page: 1427 year: 2016 ident: 2023072400195009300_bib9 publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-15-0897 contributor: fullname: Gutteridge – volume: 60 start-page: 524 year: 2015 ident: 2023072400195009300_bib7 publication-title: Mol. Cell. doi: 10.1016/j.molcel.2015.11.006 contributor: fullname: Dominguez-Brauer – volume: 10 start-page: 194 year: 2010 ident: 2023072400195009300_bib3 publication-title: Nat. Rev. Cancer. doi: 10.1038/nrc2803 contributor: fullname: Kavallaris – volume: 140 start-page: 1 year: 2017 ident: 2023072400195009300_bib8 publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2017.08.045 contributor: fullname: Borisa – volume: 9 start-page: 790 year: 2010 ident: 2023072400195009300_bib1 publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd3253 contributor: fullname: Dumontet – volume: 526 start-page: 474 year: 2017 ident: 2023072400195009300_bib2 publication-title: Int. J. Pharm. doi: 10.1016/j.ijpharm.2017.05.016 contributor: fullname: Bernabeu – volume: 24 start-page: T83 year: 2017 ident: 2023072400195009300_bib5 publication-title: Endocr. Relat. Cancer. doi: 10.1530/ERC-17-0003 contributor: fullname: Shi – volume: 8 start-page: 244 year: 2011 ident: 2023072400195009300_bib10 publication-title: Nat. Rev. Clin. Oncol. doi: 10.1038/nrclinonc.2010.228 contributor: fullname: Komlodi-Pasztor |
| SSID | ssj0004743 |
| Score | 2.5510762 |
| SecondaryResourceType | review_article |
| Snippet | Tischer and Gergely review the cell biology behind microtubule poisons and their clinical use in cancer patients. Tischer and Gergely discuss the anti-mitotic therapies in cancer. Chronic cellular proliferation is a hallmark of cancer, and therefore therapies targeting key... |
| SourceID | pubmedcentral proquest crossref pubmed |
| SourceType | Open Access Repository Aggregation Database Index Database |
| StartPage | 10 |
| SubjectTerms | Antineoplastic Agents - therapeutic use Aurora Kinase A - antagonists & inhibitors Aurora Kinase A - genetics Aurora Kinase A - metabolism Aurora Kinase B - antagonists & inhibitors Aurora Kinase B - genetics Aurora Kinase B - metabolism Cancer Cancer therapies Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell division Cell growth Cell Line, Tumor Chromosomes Clinical Trials as Topic Discussion Gene Expression Regulation, Neoplastic - drug effects Gene therapy Humans Kinases Kinesins - antagonists & inhibitors Kinesins - genetics Kinesins - metabolism Microtubules - drug effects Microtubules - metabolism Mitosis Mitosis - drug effects Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Polo-like kinase Polo-Like Kinase 1 Protein Serine-Threonine Kinases - antagonists & inhibitors Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Signal Transduction Tubulin Modulators - therapeutic use |
| Title | Anti-mitotic therapies in cancer |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/30545842 https://www.proquest.com/docview/2169245017 https://pubmed.ncbi.nlm.nih.gov/PMC6314557 |
| Volume | 218 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8NAEF60IngR31ar5CBeJNrNY5Mci_hAURBa8Bayj2AEo9h40F_vTHa7TVoP6iWENJu28-3OfruZ-YaQI5WwKMpgWUJFyNwAGLcbS5W7Isiw5ihQigRzh-_u2fUouHkMH6cV9erskoqfiq8f80r-gypcA1wxS_YPyNqHwgU4B3zhCAjD8VcYD8qqcF9gTKLqqs6kKuoAK4zlEibu9nnaHxrsEzfsT4wCk129F-MJhJg2bR32FWZo6orUqPZbNHcKMDmJurqkrI3cp24S6kTjU2UcXtDHbcB-0yN6U5doodf-zYSg6plSe8k5HwykDn2w4Bg4h7KVpk5LS-t6Zg6ykYH1O_HYT6F5apsvkiXUOcTSCLcPDTH4yARFmr9lJFSh-Vnr29uUY24dMRsO2-AXwzWyaqBxBhrldbKgyg2yrEuFfm4Sp4m1Y7F2itLRWG-R0eXF8PzaNdUtYBzEtHJjYAJKhb7IkkwKnzLpMenLhOeZCmkeKaAOPM-5Yn0pfSZCxWQQKVhhgotNYupvk075Wqpd4nh9BetOGSZJAOyWyzjgkkkBg0751PN4lxxPDJC-aRGT9EdDd0lvYp7U9PNx6lEGtg_BdXfJjraUfQrMFvii3euSqGVDewOql7c_KYunWsWc-aiRH-399rftk5Vpp-6RTvX-oQ6AEFb8sO4W3ynLXOQ |
| link.rule.ids | 230,314,780,784,885,27924,27925 |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Anti-mitotic+therapies+in+cancer&rft.jtitle=The+Journal+of+cell+biology&rft.au=Tischer%2C+Julia&rft.au=Gergely%2C+Fanni&rft.date=2019-01-07&rft.issn=0021-9525&rft.eissn=1540-8140&rft.volume=218&rft.issue=1&rft.spage=10&rft.epage=11&rft_id=info:doi/10.1083%2Fjcb.201808077&rft.externalDBID=n%2Fa&rft.externalDocID=10_1083_jcb_201808077 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9525&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9525&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9525&client=summon |