Anti-mitotic therapies in cancer

• Published in: The Journal of cell biology Vol. 218; no. 1; pp. 10 - 11
• Main Authors: Tischer, Julia, Gergely, Fanni
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 07.01.2019
• Subjects: Antineoplastic Agents - therapeutic use; Aurora Kinase A - antagonists & inhibitors; Aurora Kinase A - genetics; Aurora Kinase A - metabolism; Aurora Kinase B - antagonists & inhibitors; Aurora Kinase B - genetics; Aurora Kinase B - metabolism; Cancer; Cancer therapies; Cell Cycle Proteins - antagonists & inhibitors; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell division; Cell growth; Cell Line, Tumor; Chromosomes; Clinical Trials as Topic; Discussion; Gene Expression Regulation, Neoplastic - drug effects; Gene therapy; Humans; Kinases; Kinesins - antagonists & inhibitors; Kinesins - genetics; Kinesins - metabolism; Microtubules - drug effects; Microtubules - metabolism; Mitosis; Mitosis - drug effects; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Polo-like kinase; Polo-Like Kinase 1; Protein Serine-Threonine Kinases - antagonists & inhibitors; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins - antagonists & inhibitors; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Signal Transduction; Tubulin Modulators - therapeutic use
• ISSN: 0021-9525; 1540-8140
• DOI: 10.1083/jcb.201808077

Tischer and Gergely review the cell biology behind microtubule poisons and their clinical use in cancer patients.