Preoperative Predictors of Pathological Lymph Node Metastasis in Patients with Renal Cell Carcinoma Undergoing Retroperitoneal Lymph Node Dissection

• Published in: The Journal of urology Vol. 193; no. 4; pp. 1101 - 1107
• Main Authors: Babaian, Kara N, Kim, Dae Y, Kenney, Patrick A, Wood, Christopher G, Wong, Joseph, Sanchez, Christopher, Fang, Justin E, Gerber, Jonathan A, Didic, Adin, Wahab, Adelani, Golla, Vishnukamal, Torres, Cristina, Tamboli, Pheroze, Qiao, Wei, Matin, Surena F, Karam, Jose A
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; carcinoma; Carcinoma, Renal Cell - pathology; Carcinoma, Renal Cell - surgery; Female; Humans; kidney; Kidney Neoplasms - pathology; Kidney Neoplasms - surgery; lymph node dissection; Lymph Node Excision - methods; Lymphatic Metastasis; Male; Middle Aged; neoplasm metastasis; nephrectomy; Nomograms; Preoperative Period; Prognosis; renal cell; Retroperitoneal Space; Retrospective Studies; Urology; Young Adult; CSS; cancer specific survival; LN; OS; lactate dehydrogenase; lymph node dissection; retroperitoneal LN dissection; RPLND; C-index; Eastern Cooperative Oncology Group performance status; kidney; ECOG PS; LDH; renal cell; renal cell carcinoma; RCC; carcinoma; lymph node; neoplasm metastasis; concordance index; overall survival; nephrectomy; RFS; recurrence free survival
• ISSN: 0022-5347; 1527-3792
• DOI: 10.1016/j.juro.2014.10.096

Purpose Patients with locally advanced renal cell carcinoma represent a subset that may benefit from retroperitoneal lymph node dissection. We identified preoperative clinical predictors of positive lymph nodes in patients with renal cell carcinoma without distant metastasis who underwent retroperitoneal lymph node dissection. Materials and Methods We retrospectively analyzed data on a consecutive cohort of 1,270 patients with cTany Nany M0 renal cell carcinoma who were treated at a single institution from 1993 to 2012. Multivariate analysis was performed to determine preoperative predictors of pathologically positive lymph nodes in patients who underwent retroperitoneal lymph node dissection. A nomogram was developed to predict the probability of lymph node metastasis. Overall, cancer specific and recurrence-free survival was estimated using the Kaplan-Meier Method. Results We identified 1,270 patients with renal cell carcinoma without distant metastasis who had (564) or did not have (706) retroperitoneal lymph node dissection performed. Of the 564 patients 131 (23%) and 433 (77%) had pN1 and pN0 disease, and 60 (37%) and 29 (7.2%) had cN1pN0 and cN0pN1 disease, respectively. ECOG PS, cN stage, local symptoms and lactate dehydrogenase were associated with nodal metastasis on multivariable analysis. A nomogram was developed with a C-index of 0.89 that demonstrated excellent calibration. Differences in overall, cancer specific and recurrence-free survival among pNx, pN0 and pN1 cases were statistically significant (p <0.001). Conclusions Local symptoms, ECOG PS, cN stage and lactate dehydrogenase were independent predictors of lymph node metastasis in patients who underwent retroperitoneal lymph node dissection. Our predictive nomogram using these factors showed excellent discrimination and calibration.