Antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats
In vitro, the hydroethanolic extract of Baccharis trimera 5.0 μg/mL (Bt5) reduced the release of reactive oxygen species (RLU/30 min) in neutrophils, even after stimulation with zymosan (ZC3b) (A). In vivo, Baccharis trimera crude extract 600 mg/kg body weight (Bt) significantly reduced ROS producti...
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| Published in | Journal of ethnopharmacology Vol. 129; no. 3; pp. 381 - 386 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Shannon
Elsevier Ireland Ltd
16.06.2010
Amsterdam; New York: Elsevier Elsevier |
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| Abstract | In vitro, the hydroethanolic extract of
Baccharis trimera 5.0
μg/mL (Bt5) reduced the release of reactive oxygen species (RLU/30
min) in neutrophils, even after stimulation with zymosan (ZC3b) (A).
In vivo,
Baccharis trimera crude extract 600
mg/kg body weight (Bt) significantly reduced ROS production in the neutrophils of animals intoxicated with acetaminophen (APAP). This same effect was observed for quercetin 50
mg/kg body weight (Que) – reference substance (B).
Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as “carqueja”, it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species.
The aim of the present study was to investigate the antioxidant properties of
Baccharis trimera in the neutrophils of Fisher rats in both
in vitro and
in vivo experimental models.
In the
in vitro assay, the neutrophils of male rats were isolated and incubated with
Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0
μg/mL. In the
in vivo assay, male rats were first treated with crude extract 600
mg/kg body weight of
Baccharis trimera or with 50
mg/kg body weight of quercetin (reference substance) and then treated with 835
mg/kg of acetaminophen (APAP) after 24
h.
The hydroethanolic extract of
Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the
in vitro and
in vivo experimental models. Therefore confirming its antioxidant effect.
The results of this study confirm the antioxidant effect of Baccharis trimera. |
|---|---|
| AbstractList | Ethnopharmacological relevance - Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species. Aim of the study - The aim of the present study was to investigate the antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats in both in vitro and in vivo experimental models. Material and methods - In the in vitro assay, the neutrophils of male rats were isolated and incubated with Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0 kg/mL. In the in vivo assay, male rats were first treated with crude extract 600 mg/kg body weight of Baccharis trimera or with 50 mg/kg body weight of quercetin (reference substance) and then treated with 835 mg/kg of acetaminophen (APAP) after 24 h. Results - The hydroethanolic extract of Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the in vitro and in vivo experimental models. Therefore confirming its antioxidant effect. Conclusion - The results of this study confirm the antioxidant effect of Baccharis trimera. In vitro, the hydroethanolic extract of Baccharis trimera 5.0 μg/mL (Bt5) reduced the release of reactive oxygen species (RLU/30 min) in neutrophils, even after stimulation with zymosan (ZC3b) (A). In vivo, Baccharis trimera crude extract 600 mg/kg body weight (Bt) significantly reduced ROS production in the neutrophils of animals intoxicated with acetaminophen (APAP). This same effect was observed for quercetin 50 mg/kg body weight (Que) – reference substance (B). Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as “carqueja”, it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species. The aim of the present study was to investigate the antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats in both in vitro and in vivo experimental models. In the in vitro assay, the neutrophils of male rats were isolated and incubated with Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0 μg/mL. In the in vivo assay, male rats were first treated with crude extract 600 mg/kg body weight of Baccharis trimera or with 50 mg/kg body weight of quercetin (reference substance) and then treated with 835 mg/kg of acetaminophen (APAP) after 24 h. The hydroethanolic extract of Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the in vitro and in vivo experimental models. Therefore confirming its antioxidant effect. The results of this study confirm the antioxidant effect of Baccharis trimera. ETHNOPHARMACOLOGICAL RELEVANCEBaccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species.AIM OF THE STUDYThe aim of the present study was to investigate the antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats in both in vitro and in vivo experimental models.MATERIAL AND METHODSIn the in vitro assay, the neutrophils of male rats were isolated and incubated with Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0 microg/mL. In the in vivo assay, male rats were first treated with crude extract 600 mg/kg body weight of Baccharis trimera or with 50 mg/kg body weight of quercetin (reference substance) and then treated with 835 mg/kg of acetaminophen (APAP) after 24 h.RESULTSThe hydroethanolic extract of Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the in vitro and in vivo experimental models. Therefore confirming its antioxidant effect.CONCLUSIONThe results of this study confirm the antioxidant effect of Baccharis trimera. Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species. The aim of the present study was to investigate the antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats in both in vitro and in vivo experimental models. In the in vitro assay, the neutrophils of male rats were isolated and incubated with Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0 microg/mL. In the in vivo assay, male rats were first treated with crude extract 600 mg/kg body weight of Baccharis trimera or with 50 mg/kg body weight of quercetin (reference substance) and then treated with 835 mg/kg of acetaminophen (APAP) after 24 h. The hydroethanolic extract of Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the in vitro and in vivo experimental models. Therefore confirming its antioxidant effect. The results of this study confirm the antioxidant effect of Baccharis trimera. Ethnopharmacological relevance: Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as “carqueja”, it has been popularly used to treat liver diseases, diabetes, as well as digestive disorders. Other studies have described the hepatoprotective, antioxidant and anti-inflammatory activities of the species. Aim of the study: The aim of the present study was to investigate the antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats in both in vitro and in vivo experimental models. Material and methods: In the in vitro assay, the neutrophils of male rats were isolated and incubated with Baccharis trimera extract at concentrations of 0.5, 5.0 and 50.0μg/mL. In the in vivo assay, male rats were first treated with crude extract 600mg/kg body weight of Baccharis trimera or with 50mg/kg body weight of quercetin (reference substance) and then treated with 835mg/kg of acetaminophen (APAP) after 24h. Results: The hydroethanolic extract of Baccharis trimera reduced the release of reactive oxygen species in the neutrophils in both the in vitro and in vivo experimental models. Therefore confirming its antioxidant effect. Conclusion: The results of this study confirm the antioxidant effect of Baccharis trimera. |
| Author | Chaves, Míriam Martins Pedrosa, Maria Lucia Silva, Marcelo Eustáquio Costa, Daniela Caldeira Silva, Lucas Dornela Rossoni, Joamyr Victor Humberto, Jorge Luiz Pádua, Bruno da Cruz |
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| Keywords | Reactive oxygen species Baccharis trimera Antioxidant Neutrophils Rat Pharmacognosy Rodentia Compositae Medicinal plant Vertebrata Mammalia Folk medicine Dicotyledones Animal Angiospermae Plant origin Spermatophyta Neutrophil |
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fullname: Nogueira-Machado |
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| Snippet | In vitro, the hydroethanolic extract of
Baccharis trimera 5.0
μg/mL (Bt5) reduced the release of reactive oxygen species (RLU/30
min) in neutrophils, even... Ethnopharmacological relevance: Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as “carqueja”, it has been popularly used to... Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to treat liver diseases, diabetes, as... ETHNOPHARMACOLOGICAL RELEVANCEBaccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to treat... Ethnopharmacological relevance - Baccharis trimera (Less.) (Asteraceae) is a native plant of Brazil. Also known as "carqueja", it has been popularly used to... |
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| SubjectTerms | acetaminophen Acetaminophen - pharmacology Alanine Transaminase - blood animal models Animals Antioxidant antioxidant activity antioxidants Antioxidants - isolation & purification Antioxidants - pharmacology Aspartate Aminotransferases - blood Asteraceae Baccharis Baccharis - chemistry Baccharis trimera Biological and medical sciences Cells, Cultured chemical concentration cultured cells dosage dose response Dose-Response Relationship, Drug General pharmacology Male Medical sciences medicinal plants medicinal properties Neutrophils Neutrophils - drug effects Neutrophils - enzymology Neutrophils - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Components, Aerial - chemistry plant extracts Plant Extracts - isolation & purification Plant Extracts - pharmacology Quercetin - pharmacology Rats Rats, Inbred F344 Reactive oxygen species Reactive Oxygen Species - metabolism Time Factors Zymosan - pharmacology |
| Title | Antioxidant properties of Baccharis trimera in the neutrophils of Fisher rats |
| URI | https://dx.doi.org/10.1016/j.jep.2010.04.018 https://www.ncbi.nlm.nih.gov/pubmed/20430095 https://search.proquest.com/docview/733153090 https://search.proquest.com/docview/754870039 |
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