Relationships between Inflammation and Age-Related Neurocognitive Changes

The relationship between inflammation and age-related neurocognitive changes is significant, which may relate to the age-related immune dysfunctions characterized by the senescence of immune cells and elevated inflammatory markers in the peripheral circulation and the central nervous system. In this...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 23; no. 20; p. 12573
Main Authors Jin, Run, Chan, Aidan Kai Yeung, Wu, Jingsong, Lee, Tatia Mei Chun
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.10.2022
MDPI
Subjects
Age
Aging
Aging - pathology
Alzheimer's disease
Animal cognition
Autoimmune diseases
brain
Brain research
Central Nervous System
Chemokines
Cholesterol
Cognition
Cognition - physiology
Cognitive ability
Cytokines
DNA damage
Homeostasis
Humans
Immune system
Inflammation
Kinases
Lipid metabolism
Memory
Mitochondrial DNA
Neurocognitive Disorders
Neurodegeneration
Neurogenesis
Older people
Peripheral circulation
Physiology
Proteins
Review
Roles
Senescence
Tumor necrosis factor-TNF
neurodegeneration
aging
cognition
brain
inflammation
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Summary:The relationship between inflammation and age-related neurocognitive changes is significant, which may relate to the age-related immune dysfunctions characterized by the senescence of immune cells and elevated inflammatory markers in the peripheral circulation and the central nervous system. In this review, we discuss the potential mechanisms, including the development of vascular inflammation, neuroinflammation, organelle dysfunctions, abnormal cholesterol metabolism, and glymphatic dysfunctions as well as the role that the key molecules play in the immune-cognition interplay. We propose potential therapeutic pharmacological and behavioral strategies for ameliorating age-related neurocognitive changes associated with inflammation. Further research to decipher the multidimensional roles of chronic inflammation in normal and pathological aging processes will help unfold the pathophysiological mechanisms underpinning neurocognitive disorders. The insight gained will lay the path for developing cost-effective preventative measures and the buffering or delaying of age-related neurocognitive decline.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms232012573