Research Progress and Challenges in the Treatment of Central Nervous System Metastasis of Non-Small Cell Lung Cancer

• Published in: Cells (Basel, Switzerland) Vol. 10; no. 10; p. 2620
• Main Authors: Wang, Bin, Guo, Hanfei, Xu, Haiyang, Yu, Hongquan, Chen, Yong, Zhao, Gang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.10.2021; MDPI
• Subjects: brain metastasis; Brain Neoplasms - secondary; Brain Neoplasms - therapy; Cancer therapies; Carcinoma, Non-Small-Cell Lung - pathology; Central nervous system; central nervous system metastasis; Chemotherapy; Epidermal growth factor; Humans; Immunotherapy; Immunotherapy - methods; leptomeningeal metastasis; Lung cancer; Lung Neoplasms - pathology; Medical prognosis; Metastases; Metastasis; Morbidity; Mortality; Mutation; Nervous system; non-small cell lung cancer; Non-small cell lung carcinoma; Patients; Quality of life; Radiation therapy; radiotherapy; Review; Small cell lung carcinoma; Steroids; Surgery; Treatment Outcome; Tumors; non-small cell lung cancer; central nervous system metastasis; targeted therapy; leptomeningeal metastasis; immunotherapy; radiotherapy; brain metastasis; chemotherapy
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells10102620

Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors and has high morbidity and mortality rates. Central nervous system (CNS) metastasis is one of the most frequent complications in patients with NSCLC and seriously affects the quality of life (QOL) and overall survival (OS) of patients, with a median OS of untreated patients of only 1–3 months. There are various treatment methods for NSCLC CNS metastasis, including surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, which do not meet the requirements of patients in terms of improving OS and QOL. There are still many problems in the treatment of NSCLC CNS metastasis that need to be solved urgently. This review summarizes the research progress in the treatment of NSCLC CNS metastasis to provide a reference for clinical practice.