DNA Compaction and Charge Neutralization Regulated by Divalent Ions in very Low pH Solution

• Published in: Polymers Vol. 11; no. 2; p. 337
• Main Authors: Gao, Tianyong, Zhang, Wei, Wang, Yanwei, Yang, Guangcan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.02.2019; MDPI
• Subjects: Cell cycle; charge neutralization; Divalent cations; DNA compaction; magnesium ions; Microscopy; pH regulation; Phase transitions; United States > US; charge neutralization; magnesium ions; pH regulation; DNA compaction

DNA conformation is strongly dependent on the valence of counterions in solution, and a valence of at least three is needed for DNA compaction. Recently, we directly demonstrated DNA compaction and its regulation, mediated by divalent cations, by lowering the pH of a solution. In the present study,...