Progression and regression of fibrosis in viral hepatitis in the treatment era: the Beijing classification

• Published in: Modern pathology Vol. 31; no. 8; pp. 1191 - 1200
• Main Authors: Theise, Neil D., Jia, Jidong, Sun, Yameng, Wee, Aileen, You, Hong
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2018; Elsevier Limited
• Subjects: 692/53/2422; 692/699/1503/234/2513/1549; Biopsy; Classification; Disease Progression; Fibrosis; Hepatitis; Hepatitis B; Hepatitis B, Chronic - pathology; Hepatitis C; Hepatitis C, Chronic - pathology; Humans; Laboratory Medicine; Liver Cirrhosis - classification; Liver Cirrhosis - pathology; Liver Cirrhosis - virology; Liver diseases; Medicine; Medicine & Public Health; Pathology; Review Article; Beijing China
• ISSN: 0893-3952; 1530-0285; 1530-0285
• DOI: 10.1038/s41379-018-0048-0

In this new era of successful long term suppression of hepatitis B viral replication and consistent eradication of hepatitis C virus the necessity for routine pre-treatment biopsies has often been eliminated. Thus, whether there is utility to perform liver biopsy in chronic viral hepatitis is undergoing re-examination. In response to these changing needs, we have developed a new staging system, the Beijing Classification , for assessment of biopsy specimens from patients with chronic viral hepatitis. The most important novelty of the Beijing Classification is that it includes not only extent (stage) of fibrosis, but the quality of fibrosis, namely if the specimen shows predominantly regressive vs. progressive features (or is indeterminantly balanced between the two), the P-I-R score. This histologic distinction between regressive and progressive fibrosis, while invoked in this particular setting of chronic viral hepatitis, may have applicability to all forms of chronic liver disease. Thus, the review contains a description of the concepts of regression and progression with the aim of empowering pathologists to apply them in histopathologic-clinical correlation research as well as in the specific clinical setting for which it was developed. Also, in light of changing clinical needs, grading of necroinflammatory activity and staging of fibrosis are simplified into three point scales. These simplifications should aid the general diagnostic pathologist in being comfortable and confident in assessing biopsy specimens as the criteria for their distinction are far more precise, with significantly reduced “gray zones” of prior grading/staging systems.