Trabecular outflow facility determined by fluorophotometry in human subjects

• Published in: Experimental eye research Vol. 48; no. 5; pp. 621 - 625
• Main Authors: Hayashi, Mieko, Yablonski, Michael E., Novack, Gary D.
• Format: Journal Article
• Language: English
• Published: London Elsevier Ltd 01.05.1989; Elsevier
• Subjects: Aqueous Humor - drug effects; Aqueous Humor - physiology; Biological and medical sciences; Eye and associated structures. Visual pathways and centers. Vision; Female; Fluorometry; fluorophotometry; Fundamental and applied biological sciences. Psychology; Humans; Intraocular Pressure - drug effects; levobunolol; Male; Middle Aged; non-invasive; ocular hypertensive patients; pilocarpine; Pilocarpine - pharmacology; Trabecular Meshwork - drug effects; Trabecular Meshwork - physiology; trabecular outflow facility; uveoscleral outflow; Vertebrates: nervous system and sense organs; fluorophotometry; pilocarpine; non-invasive; trabecular outflow facility; uveoscleral outflow; ocular hypertensive patients; levobunolol; Glaucoma; Human; Eye; Method; Fluorophotometry; Trabecular Meshwork
• ISSN: 0014-4835; 1096-0007
• DOI: 10.1016/0014-4835(89)90004-3

We studied a new fluorophotometric method to determine trabecular outflow facility in man. Pilocarpine was selected to evaluate this non-invasive method, since its primary ocular hypotensive effect is to increase trabecular outflow facility. Levobunolol was used to decrease intraocular pressure and aqueous humor flow required for the calculation of trabecular outflow facility. In ten ocular hypertensive patients trabecular outflow facility in the pilocarpine-treated eyes was 0·42±0·16 ( s.d.) μl min −1 mmHg −1 compared with 0·17±0·14 μl min −1 mmHg −1 in the vehicle-treated eyes ( P < 0·004). An ocular hypotensive additivity was also found in the eyes treated with both drugs. It was concluded that this non-invasive fluorophotometric method may be useful in evaluating the effect of a drug on trabecular outflow facility.