Panax ginseng Fruit Has Anti-Inflammatory Effect and Induces Osteogenic Differentiation by Regulating Nrf2/HO-1 Signaling Pathway in In Vitro and In Vivo Models of Periodontitis

• Published in: Antioxidants Vol. 9; no. 12; p. 1221
• Main Authors: Kim, Eun-Nam, Kim, Tae-Young, Park, Eui Kyun, Kim, Jae-Young, Jeong, Gil-Saeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.12.2020; MDPI
• Subjects: Alkaline phosphatase; Alveolar bone; Animal models; Bone loss; Cardiovascular disease; Cbfa-1 protein; Collagen; Collagen (type I); Computed tomography; Connective tissue; Connective tissue diseases; Cyclooxygenase-2; Cytokines; Enzymes; Ginseng; Gum disease; Heme; Heme oxygenase (decyclizing); heme oxygenase-1; Herbal medicine; Inflammatory diseases; Interleukin 6; Ligaments; Lipopolysaccharides; Nitric oxide; Nitric-oxide synthase; osteogenic differentiation; Osteopontin; Oxygenase; Panax ginseng; Panax ginseng fruit extract; Periodontal diseases; Periodontal ligament; Periodontitis; Porphyromonas gingivalis; Proteins; Signal transduction; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Minneapolis Minnesota; St Louis Missouri; United States > US; China; Japan; Grand Island New York; Switzerland; Germany; Porphyromonas gingivalis; Panax ginseng fruit extract; heme oxygenase-1; osteogenic differentiation; periodontitis

Periodontitis is an infectious inflammatory disease of tissues around teeth that destroys connective tissues and is characterized by the loss of periodontal ligaments and alveolar bone. A new treatment strategy is needed owing to the limitations of the current surgical treatment method and the side...