The neutrophil-to-lymphocyte ratio as a novel independent prognostic factor for multiple metastatic lung tumors from various sarcomas

• Published in: Surgery today (Tokyo, Japan) Vol. 51; no. 1; pp. 127 - 135
• Main Authors: Yamamoto, Hiromasa, Namba, Kei, Yamamoto, Haruchika, Toji, Tomohiro, Soh, Junichi, Shien, Kazuhiko, Suzawa, Ken, Kurosaki, Takeshi, Otani, Shinji, Okazaki, Mikio, Sugimoto, Seiichiro, Yamane, Masaomi, Takahashi, Katsuhito, Kunisada, Toshiyuki, Oto, Takahiro, Toyooka, Shinichi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.01.2021
• Subjects: Medicine; Medicine & Public Health; Original Article; Surgery; Surgical Oncology; Metastasectomy; Neutrophil-to-lymphocyte ratio (NLR); Survival rate; Sarcoma; Metastatic lung tumor
• ISSN: 0941-1291; 1436-2813; 1436-2813
• DOI: 10.1007/s00595-020-02093-5

Purpose Sarcomas are among the most refractory malignant tumors and often recur as pulmonary metastasis. Although the presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with the prognosis of several malignancies, the relationship between the NLR and sarcoma with pulmonary metastasis is unclear. We investigated the impact of the NLR in patients who underwent surgical resection for metastatic lung tumors from various sarcomas. Methods The subjects of this retrospective study were 158 patients with metastatic lung tumors from various sarcomas, who underwent initial pulmonary metastasectomy between 2006 and 2015. We examined the clinicopathological variables, including the NLR and the characteristics of surgical procedures. Survival was estimated by the Kaplan–Meier method and prognostic factors were evaluated by multivariate analysis. Results Multivariate analysis revealed significantly better survival of the group with an NLR < 2.26 immediately before the most recent pulmonary metastasectomy, in addition to such factors as the largest resected lesion being < 22 mm, a disease-free interval of > 2 years, and 3 or more pulmonary metastasectomies. Conclusion The NLR immediately before the most recent pulmonary metastasectomy is a novel independent prognostic factor, which may be helpful when considering repeated pulmonary metastasectomy.