Cargo trafficking between endosomes and the trans-Golgi network

The retrograde membrane transport pathways from endosomes to the trans -Golgi network (TGN) are now recognized as critical intracellular pathways to recycle and shuttle a selective subgroup of membrane proteins, including sorting receptors, membrane-bound enzymes, transporters, as well as providing...

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Published inHistochemistry and cell biology Vol. 140; no. 3; pp. 307 - 315
Main Authors Chia, Pei Zhi Cheryl, Gunn, Priscilla, Gleeson, Paul A.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2013
Springer Nature B.V
Subjects
Animals
Bacteria
Biochemistry
Biological Transport
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Endosomes - metabolism
Membranes
Proteins
Review
Toxins
trans-Golgi Network - metabolism
Golgi network
Membrane trafficking
Retrograde transport
Membrane recycling
Endosomes
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Summary:The retrograde membrane transport pathways from endosomes to the trans -Golgi network (TGN) are now recognized as critical intracellular pathways to recycle and shuttle a selective subgroup of membrane proteins, including sorting receptors, membrane-bound enzymes, transporters, as well as providing an avenue for the intracellular transport of various bacterial toxins. Multiple pathways from endosomes to the TGN have now been defined which differ between the cargo transported and the machinery used. Here, we review advances in these pathways and the requirement for TGN organization, and also discuss the development of unbiased analytical approaches to quantitatively track cargo that use these endosome-to-TGN pathways.
Bibliography:ObjectType-Article-2
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ISSN:0948-6143
1432-119X
DOI:10.1007/s00418-013-1125-6