Facile one-pot synthesis of thio and selenourea derivatives: A new class of potent urease inhibitors

• Published in: Bioorganic & medicinal chemistry Vol. 17; no. 22; pp. 6387 - 6391
• Main Authors: Sivapriya, Kirubakaran, Suguna, Perumal, Banerjee, Arun, Saravanan, Vadivelu, Rao, Desirazu N., Chandrasekaran, Srinivasan
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.11.2007; Elsevier
• Subjects: Biological and medical sciences; Canavalia - enzymology; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Drug Evaluation, Preclinical; Enzyme Inhibitors - chemical synthesis; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Life Sciences & Biomedicine; Medical sciences; Miscellaneous; Models, Molecular; Molecular Structure; Molybdenum - chemistry; Organoselenium Compounds - chemical synthesis; Organoselenium Compounds - chemistry; Organoselenium Compounds - pharmacology; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Physical Sciences; Science & Technology; Selenourea; Tetraselenotungstate; Tetrathiomolybdate; Thiourea; Thiourea - chemical synthesis; Thiourea - chemistry; Thiourea - pharmacology; Urea - analogs & derivatives; Urea - chemical synthesis; Urea - chemistry; Urea - pharmacology; Urease - antagonists & inhibitors; Urease inhibition; Urease inhibition; Tetraselenotungstate; Thiourea; Tetrathiomolybdate; Selenourea; REAGENT; thiourea; urease inhibition; CHEMISTRY; ANTIFUNGAL; tetraselenotungstate; TETRAETHYLAMMONIUM TETRASELENOTUNGSTATE; SELENIUM; selenourea; tetrathiomolybdate; CHLORIDE; One pot reaction; Enzyme; Enzyme inhibitor; Urease; Thioureas; In vitro; Biological activity; Hydrolases; Chemical synthesis; Selenoureas; Thiomolybdates
• ISSN: 0960-894X; 0968-0896; 1464-3405; 1464-3391
• DOI: 10.1016/j.bmcl.2007.07.085

A facile, one-pot synthesis of thio and selenourea derivatives is reported. Some of the derivatives showed potent inhibitory activity against urease (jack bean) in the nanomolar range. A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetraselenotungstate 2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards jack bean urease.