Facile one-pot synthesis of thio and selenourea derivatives: A new class of potent urease inhibitors
A facile, one-pot synthesis of thio and selenourea derivatives is reported. Some of the derivatives showed potent inhibitory activity against urease (jack bean) in the nanomolar range. A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate 1 and tetrasele...
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Published in | Bioorganic & medicinal chemistry Vol. 17; no. 22; pp. 6387 - 6391 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
15.11.2007
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A facile, one-pot synthesis of thio and selenourea derivatives is reported. Some of the derivatives showed potent inhibitory activity against urease (jack bean) in the nanomolar range.
A facile, one-pot synthesis of thio and selenourea derivatives from amines using tetrathiomolybdate
1 and tetraselenotungstate
2 as sulfur and selenium transfer reagents, respectively, is reported. The compounds were tested for their activity as urease inhibitors and some of the compounds showed potent activity in the nanomolar range towards
jack bean urease. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0960-894X 0968-0896 1464-3405 1464-3391 |
DOI: | 10.1016/j.bmcl.2007.07.085 |