Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists
The synthesis and the SAR of new series of NPY-1 antagonists are reported. The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising...
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Published in | Bioorganic & medicinal chemistry letters Vol. 16; no. 6; pp. 1749 - 1752 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
15.03.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The synthesis and the SAR of new series of NPY-1 antagonists are reported.
The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profile in rat. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2005.11.104 |