Host immunity to Mycobacterium tuberculosis and risk of tuberculosis: A longitudinal study among Greenlanders

• Published in: Vaccine Vol. 34; no. 48; pp. 5975 - 5983
• Main Authors: Michelsen, Sascha Wilk, M.D., Ph.D, Soborg, Bolette, M.D., Ph.D, Agger, Else Marie, M.Sc., Ph.D, Diaz, Lars Jorge, M.Sc, Hoff, Soren Tetens, M.D., Ph.D, Koch, Anders, M.D., Ph.D., MPH, Sorensen, Hans Christian Florian, M.D, Andersen, Peter, D.M.Sc., DVM, Wohlfahrt, Jan, M.Sc., D.M.Sc, Melbye, Mads, M.D., D.M.Sc
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 21.11.2016; Elsevier Limited
• Subjects: Adolescent; Adult; Allergy and Immunology; Antigens; Antigens, Bacterial - immunology; Child; Child, Preschool; Cohort Studies; Confidence intervals; Disease Progression; Epidemiologic Studies; Epidemiology; Female; Greenland - epidemiology; Humans; Immune response; Immunity; Immunity, Cellular; Infections; Interferon-gamma - biosynthesis; Inuit; Latent Tuberculosis - epidemiology; Latent Tuberculosis - immunology; Longitudinal Studies; Male; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Population; Population studies; Risk Factors; Studies; Tuberculosis; Tuberculosis - epidemiology; Tuberculosis - immunology; Tuberculosis Vaccines - administration & dosage; Tuberculosis Vaccines - immunology; Vaccines; Vectors (Biology); Young Adult; Denmark; Antigens; Tuberculosis; Vaccines; Immunity; Epidemiology
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2016.09.047

Highlights • Immunity to promising latent TB vaccine antigens did not reduce risk of TB. • Immunity to latent TB antigens was observed among individuals categorised as not Mtb -infected. • A large follow-up study with a clinical outcome in a setting with high TB transmission. • Findings are not influenced by cross-reactions attributed to non tuberculous mycobacteria.