Cadherin Signaling in Cancer and Autoimmune Diseases

Cadherins mediate cell-cell adhesion through a dynamic process that is strongly dependent on the cellular context and signaling. Cadherin regulation reflects the interplay between fundamental cellular processes, including morphogenesis, proliferation, programmed cell death, surface organization of r...

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Published inInternational journal of molecular sciences Vol. 22; no. 24; p. 13358
Main Authors Sisto, Margherita, Ribatti, Domenico, Lisi, Sabrina
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 12.12.2021
MDPI
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Summary:Cadherins mediate cell-cell adhesion through a dynamic process that is strongly dependent on the cellular context and signaling. Cadherin regulation reflects the interplay between fundamental cellular processes, including morphogenesis, proliferation, programmed cell death, surface organization of receptors, cytoskeletal organization, and cell trafficking. The variety of molecular mechanisms and cellular functions regulated by cadherins suggests that we have only scratched the surface in terms of clarifying the functions mediated by these versatile proteins. Altered cadherins expression is closely connected with tumorigenesis, epithelial-mesenchymal transition (EMT)-dependent fibrosis, and autoimmunity. We review the current understanding of how cadherins contribute to human health and disease, considering the mechanisms of cadherin involvement in diseases progression, as well as the clinical significance of cadherins as therapeutic targets.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222413358