Senescent Cells in Cancer: Wanted or Unwanted Citizens

Over recent decades, the field of cellular senescence has attracted considerable attention due to its association with aging, the development of age-related diseases and cancer. Senescent cells are unable to proliferate, as the pathways responsible for initiating the cell cycle are irreversibly inhi...

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Published inCells (Basel, Switzerland) Vol. 10; no. 12; p. 3315
Main Authors Niklander, Sven E., Lambert, Daniel W., Hunter, Keith D.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.11.2021
MDPI
Subjects
Aging
Animals
Apoptosis
Biomarkers, Tumor - metabolism
Cancer
Cancer therapies
Carcinogenesis
Cell cycle
Cell division
Cell growth
Cellular Senescence
Cytokines
DNA damage
DNA methylation
Enzymes
Fibroblasts
Gene expression
Genotype & phenotype
Humans
Inflammation
Models, Biological
Molecular modelling
Mortality
Mutation
Neoplasms - pathology
Oxidative stress
Paracrine signalling
Phenotypes
Review
SASP
Secretome
Senescence
Senescence-Associated Secretory Phenotype
senolytics
senomorphics
Signal Transduction
Stem cells
Telomerase
senescence
senolytics
cancer
carcinogenesis
SASP
senomorphics
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Summary:Over recent decades, the field of cellular senescence has attracted considerable attention due to its association with aging, the development of age-related diseases and cancer. Senescent cells are unable to proliferate, as the pathways responsible for initiating the cell cycle are irreversibly inhibited. Nevertheless, senescent cells accumulate in tissues and develop a pro-inflammatory secretome, known as the senescence-associated secretory phenotype (SASP), which can have serious deleterious effects if not properly regulated. There is increasing evidence suggesting senescent cells contribute to different stages of carcinogenesis in different anatomical sites, mainly due to the paracrine effects of the SASP. Thus, a new therapeutic field, known as senotherapeutics, has developed. In this review, we aim to discuss the molecular mechanisms underlying the senescence response and its relationship with cancer development, focusing on the link between senescence-related inflammation and cancer. We will also discuss different approaches to target senescent cells that might be of use for cancer treatment.
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ISSN:2073-4409
2073-4409
DOI:10.3390/cells10123315