Oral and Cutaneous Lymphomas other than Mycosis Fungoides and Sézary Syndrome in a Mexican Cohort: Recategorization and Evaluation of International Geographical Disparities

• Published in: Indian journal of dermatology Vol. 62; no. 2; pp. 158 - 167
• Main Authors: Hernández-Salazar, Amparo, García-Vera, Jorge Andrés, Charli-Joseph, Yann, Ortiz-Pedroza, Guadalupe, Méndez-Flores, Silvia, Orozco-Topete, Rocío, Morales-Leyte, Ana Lilia, Domínguez-Cherit, Judith, Lome-Maldonado, Carmen
• Format: Journal Article
• Language: English
• Published: India Medknow Publications & Media Pvt. Ltd 01.03.2017; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Classification; Fungal infections; IJD Symposium; Lymphocytes; Lymphoma; Morphology; Population; Primary cutaneous lymphomas; primary oral lymphomas; secondary cutaneous lymphomas; Skin; Studies; Ulcers; United States > US; secondary cutaneous lymphomas; Primary cutaneous lymphomas; primary oral lymphomas
• ISSN: 0019-5154; 1998-3611
• DOI: 10.4103/ijd.IJD_34_17

Nonmycosis fungoides/Sézary syndrome (non-MF/SS) primary cutaneous lymphomas (PCL) are currently categorized under the 2005-World Health Organization/European Organization for Research and Treatment of Cancer (WHO-EORTC) classification for PCL. These differ in behavior from secondary cutaneous lymphomas (SCL) and to lymphomas limited to the oral cavity (primary oral lymphomas [POL]) both categorized under the 2016-WHO classification for lymphoid neoplasms. This study aims to report the first series of non-MF/SS PCL, SCL, and POL in a Mexican cohort, examine the applicability of current classification systems and compare our findings with those from foreign cohorts. Eighteen non-MF/SS PCL, four SCL, and two POL with available tissue for morphology and immunophenotypic assessment were reclassified according to the 2005-WHO/EORTC and 2016-WHO classifications. Non-MF/SS PCLs were primarily of T-cell origin (61%) where CD30+ lymphoproliferative disorders predominated, followed by Epstein-Barr virus-induced lymphomas, and peripheral T-cell lymphomas, not otherwise specified. Primary cutaneous B-cell lymphomas (BCL) were primarily of follicle center cell origin followed by postgerminal lymphomas of the diffuse large BCL variety. Most non-MF/SS PCL, SCL, and POL can be adequately categorized according to the 2005-WHO/EORTC and 2016-WHO classification systems, even when dealing with clinically atypical cases. The relative frequencies in our cohort hold closer similarities to Asian registries than from those of Europe/USA, supporting the concept of individual and/or racial susceptibility, and the notion of geographical variances in the rate of lymphomas. In particular, such disparity may arise from viral-induced lymphomas which might show partial geographical restriction.