Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial

• Published in: Nutrients Vol. 12; no. 7; p. 1954
• Main Authors: Ganda Mall, John-Peter, Fart, Frida, Sabet, Julia A., Lindqvist, Carl Mårten, Nestestog, Ragnhild, Hegge, Finn Terje, Keita, Åsa V., Brummer, Robert J., Schoultz, Ida
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.06.2020; MDPI
• Subjects: Acute Disease; Aged; Aged, 80 and over; Avena; Bacteria; beta-Glucans - administration & dosage; clinical trial; Clinical trials; Creatinine; Dietary Fiber - administration & dosage; dietary fibres; Dietary Supplements; elderly; Female; Food; Gastrointestinal Microbiome - drug effects; gut health; Humans; Indomethacin - adverse effects; intestinal barrier function; Intestinal Diseases - chemically induced; Intestinal Diseases - therapy; intestinal permeability; Male; Microbiota; NSAIDs; Older people; Permeability; Permeability - drug effects; Population; prebiotics; Questionnaires; Sugar; Treatment Outcome; Triticum; Urine; Xylans - administration & dosage; Sweden; clinical trial; gut health; intestinal permeability; dietary fibres; intestinal barrier function; NSAIDs; elderly; prebiotics
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12071954

The effect of dietary fibres on intestinal barrier function has not been well studied, especially in the elderly. We aimed to investigate the potential of the dietary fibres oat β-glucan and wheat arabinoxylan to strengthen the intestinal barrier function and counteract acute non-steroid anti-inflammatory drug (indomethacin)-induced hyperpermeability in the elderly. A general population of elderly subjects (≥65 years, n = 49) was randomised to a daily supplementation (12g/day) of oat β-glucan, arabinoxylan or placebo (maltodextrin) for six weeks. The primary outcome was change in acute indomethacin-induced intestinal permeability from baseline, assessed by an in vivo multi-sugar permeability test. Secondary outcomes were changes from baseline in: gut microbiota composition, systemic inflammatory status and self-reported health. Despite a majority of the study population (85%) showing a habitual fibre intake below the recommendation, no significant effects on acute indomethacin-induced intestinal hyperpermeability in vivo or gut microbiota composition were observed after six weeks intervention with either dietary fibre, compared to placebo.