Golgi Apparatus Regulates Plasma Membrane Composition and Function

Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-...

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Published inCells (Basel, Switzerland) Vol. 11; no. 3; p. 368
Main Authors Agliarulo, Ilenia, Parashuraman, Seetharaman
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.01.2022
MDPI
Subjects
Animals
Biosynthesis
Cell division
Cell Membrane - metabolism
Enzymes
Genetic disorders
glycosylation
Golgi apparatus
Golgi Apparatus - metabolism
Lipid composition
Lipids
Localization
Mammals
Membrane composition
membrane contact sites
Membrane Lipids - metabolism
palmitoylation
Polymers
Protein Transport
Proteins
Review
Sugar
TGN sorting
trans-Golgi Network - metabolism
glycosylation
TGN sorting
membrane contact sites
palmitoylation
Golgi apparatus
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Summary:Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11030368