Anti-Inflammatory and Antibothropic Properties of Jatropha Elliptica , a Plant from Brazilian Cerrado Biome

• Published in: Advanced pharmaceutical bulletin Vol. 6; no. 4; pp. 573 - 579
• Main Authors: Ferreira-Rodrigues, Sára Cósta, Rodrigues, Cássio Milhomens, Dos Santos, Marcio Galdino, Gautuz, Jean Antonio Abraham, Silva, Magali Glauzer, Cogo, José Carlos, Batista-Silva, Camila, Dos Santos, Cleiton Pita, Groppo, Francisco Carlos, Cogo-Müller, Karina, Oshima-Franco, Yoko
• Format: Journal Article
• Language: English
• Published: Iran Tabriz University of Medical Sciences 01.12.2016
• Subjects: Bothrops jararacussu; Edema; Inflammation; Jatropha elliptica; Myonecrosis; Neurotoxicity; Bothrops jararacussu; Edema; Neurotoxicity; Inflammation; Myonecrosis; Jatropha elliptica
• ISSN: 2228-5881; 2251-7308
• DOI: 10.15171/apb.2016.071

The aim of this study was to evaluate the antibothropic and anti-inflammatory properties of Phytochemical screening and thin-layer chromatography (TLC) assays were performed on hydroalcoholic extract (TE) in order to observe its main constituents. The antibothropic activity of TE was evaluated by the neuromuscular blockade caused by venom (Bjssu), in a mouse phrenic nerve-diaphragm model (PND). A quantitative histological study was carried out to observe a possible protection of TE against the venom myotoxicity. The anti-inflammatory activity was also evaluated in two models, Bjssu-induced paw edema, and carrageenan-induced neutrophils migration in the peritoneal cavity. TLC analysis revealed several compounds in TE, such as saponins, alkaloids, and phenolic constituents. TE was able to neutralize the blockade and the myotoxicity induced by venom, when it was pre-incubated for 30 min with venom. In addition, it showed anti-inflammatory activity, inducing less neutrophils migration and reducing paw edema. showed both antibothropic and anti-inflammatory properties.