Long-term Virologic and Immunologic Responses in Human Immunodeficiency Virus Type 1-Infected Children Treated with Indinavir, Zidovudine, and Lamivudine

• Published in: The Journal of infectious diseases Vol. 183; no. 7; pp. 1116 - 1120
• Main Authors: Jankelevich, Shirley, Mueller, Brigitta U., Mackall, Crystal L., Smith, Sharon, Zwerski, Sheryl, Wood, Lauren V., Zeichner, Steven L., Serchuck, Leslie, Steinberg, Seth M., Nelson, Robert P., Sleasman, John W., Nguyen, Bach-Yen, Pizzo, Philip A., Yarchoan, Robert
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.04.2001; University of Chicago Press; Oxford University Press
• Subjects: Adolescent; AIDS; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; CD4 antigen; CD4 Antigens - analysis; CD4 Lymphocyte Count; Child; Child health services; Child, Preschool; Concise Communications; Dosage; Drug Therapy, Combination; Female; Follow-Up Studies; HIV; HIV - isolation & purification; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV Protease Inhibitors - therapeutic use; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunology; Indinavir; Indinavir - therapeutic use; Infectious diseases; Lamivudine; Lamivudine - therapeutic use; Leukocyte Common Antigens - analysis; Male; Medical sciences; Pharmacology. Drug treatments; Protease inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; RNA; RNA, Viral - analysis; T lymphocytes; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Virology; Viruses; Zidovudine; Zidovudine - therapeutic use; RNA-directed DNA polymerase; HIV-1 virus; Suppression; Reverse transcriptase inhibitor; T-Lymphocyte; Viral load; Child; Pyrimidine nucleoside; Indinavir; Human; Immunopathology; Enzyme; Transferases; Retroviridae; Enzyme inhibitor; Lamivudine; AIDS; Lentivirus; Immune deficiency; Infection; Virus; Peptidases; Nucleotidyltransferases; Viral disease; Dideoxynucleoside; Hydrolases; Replication; Human immunodeficiency virus; Nucleosidic analog; Zidovudine; Protease inhibitor
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1086/319274

Virologic and immunologic responses were examined for 33 human immunodeficiency virus (HIV)–infected children who participated for ⩾96 weeks in a phase 1/2 protocol of 16 weeks of indinavir monotherapy, followed by the addition of zidovudine and lamivudine. At week 96, a median increase of 199 CD4+ T cells/μL and a median decrease of 0.74 log10 HIV RNA copies/mL were observed. The relationship between control of viral replication and CD4+ T cell count was examined. Patients were categorized into 3 response groups on the basis of duration and extent of control of viral replication. Of 21 children with a transient decrease in virus load of ⩾0.7 log10 HIV RNA copies/mL from baseline, 7 experienced sustained increases in CD4+, CD4+CD45RA+, and CD4+CD45RO+ T cell counts. CD4+CD45RA+ (naive) T cells were the major contributor to CD4+ T cell expansion. Continued long-term immunologic benefit may be experienced by a subset of children, despite only transient virologic suppression